240903

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4791080..4791596 Replicon chromosome
Accession NZ_CP094991
Organism Klebsiella pneumoniae strain SCPM-O-B-8919 (12PKP/19c)

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag KF986_RS23355 Protein ID WP_004178374.1
Coordinates 4791080..4791364 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag KF986_RS23360 Protein ID WP_002886901.1
Coordinates 4791354..4791596 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF986_RS23330 (KF986_023330) 4786497..4786760 - 264 WP_025987940.1 PTS sugar transporter subunit IIB -
KF986_RS23335 (KF986_023335) 4786890..4787063 + 174 WP_019725541.1 hypothetical protein -
KF986_RS23340 (KF986_023340) 4787066..4787809 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
KF986_RS23345 (KF986_023345) 4788166..4790304 + 2139 WP_019725540.1 anaerobic ribonucleoside-triphosphate reductase -
KF986_RS23350 (KF986_023350) 4790612..4791076 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
KF986_RS23355 (KF986_023355) 4791080..4791364 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KF986_RS23360 (KF986_023360) 4791354..4791596 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KF986_RS23365 (KF986_023365) 4791674..4793584 - 1911 WP_019725539.1 PRD domain-containing protein -
KF986_RS23370 (KF986_023370) 4793607..4794761 - 1155 WP_004178372.1 lactonase family protein -
KF986_RS23375 (KF986_023375) 4794828..4795568 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T240903 WP_004178374.1 NZ_CP094991:c4791364-4791080 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T240903 NZ_LT853884:c23596-23312 [Xanthomonas fragariae]
GTGCCACACCTGATTTGGACGCCGCCGGCACTCGCGGACGTTCAACGCCTGTATCGTTTCCTTGCTCCGAAGGATGCCGA
CGCTGCCCGCCGTGCGGTGCAAGCAATCCGCGCGCAGGTCAAAATCCTGGCGCATCAGCCTCGCATCGGGCGACCCGTCG
AGGACATGGCCCCCGAGTTCCGCGATTGGCTCATCGACTTTGGCGATAGCGGCTACGTGGCCCGGTATCGCATCAACGAA
AACATGGTGACGATCTTGGCCGTTCGGCACCAAAAGGAAGCGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT240903 WP_002886901.1 NZ_CP094991:c4791596-4791354 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT240903 NZ_LT853884:c23862-23584 [Xanthomonas fragariae]
ATGGCATCGCCAACCTCGCTCAAGCTCGATGACGAGCTGAAAGGGCGTGTGCAACACCTCGCCCAAACCCAGCGCCGCAC
GCCGCACTGGATCATGCGTGAAGCCATTGCGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGACCTTCAAACAAGACGCGC
TCCGCGCTTGGGAGGACTATCAGCGCACCGGCCTGCACCTGACGCTCGAAGAAACCGATGCGTGGCTGGCCAAGCTCGAA
GCTGGCGAGGATGCGGAACTGCCAGCGTGCCACACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References