Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4051880..4052499 Replicon chromosome
Accession NZ_CP094991
Organism Klebsiella pneumoniae strain SCPM-O-B-8919 (12PKP/19c)

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag KF986_RS19855 Protein ID WP_002892050.1
Coordinates 4052281..4052499 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag KF986_RS19850 Protein ID WP_002892066.1
Coordinates 4051880..4052254 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF986_RS19840 (KF986_019840) 4047032..4048225 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
KF986_RS19845 (KF986_019845) 4048248..4051394 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
KF986_RS19850 (KF986_019850) 4051880..4052254 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
KF986_RS19855 (KF986_019855) 4052281..4052499 + 219 WP_002892050.1 HHA domain-containing protein Toxin
KF986_RS19860 (KF986_019860) 4052662..4053228 + 567 WP_002892030.1 maltose O-acetyltransferase -
KF986_RS19865 (KF986_019865) 4053200..4053340 - 141 WP_004147370.1 hypothetical protein -
KF986_RS19870 (KF986_019870) 4053361..4053831 + 471 WP_002892026.1 YlaC family protein -
KF986_RS19875 (KF986_019875) 4053806..4055257 - 1452 WP_064145206.1 PLP-dependent aminotransferase family protein -
KF986_RS19880 (KF986_019880) 4055358..4056056 + 699 WP_004177238.1 GNAT family protein -
KF986_RS19885 (KF986_019885) 4056053..4056193 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
KF986_RS19890 (KF986_019890) 4056193..4056456 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T240900 WP_002892050.1 NZ_CP094991:4052281-4052499 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T240900 NZ_LT853882:c4236953-4236672 [Xanthomonas fragariae]
ATGATCAAGAGCATTGTCGACAAGGAAGCCGAAAAGATCTGGGTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGCATTCCGCCTGCCAACCGGC
TGGAAGCGTTGAAGGGCGAGCGGCGCGGGCAGTACAGCATCCGGATCAACGACCAGTTGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGAAATTGTCGATTACCACTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT240900 WP_002892066.1 NZ_CP094991:4051880-4052254 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT240900 NZ_LT853882:c4236653-4236363 [Xanthomonas fragariae]
ATGACAGTCCTACCCAACATCCACCCTGGTGAAATCCTGCTTGAGGAGTTCCTCGAGCCGATGGGCATCAGCCAGAACGC
ATTGGCGCGGGCCACCGGTGTGCCGCCGCGCCGTATCAACGAAATCGTGTTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCTGCAGCGCTGTGCACGACCGAGCGCTTCTGGCTAGGCCTGCAAGCCGATTACGAGCTGGAACAAGCG
CACCGCGCGCTGGGCGACCTGCCATCGCGGATCAAGCGGCTGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References