Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 817082..817739 Replicon chromosome
Accession NZ_CP094991
Organism Klebsiella pneumoniae strain SCPM-O-B-8919 (12PKP/19c)

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KF986_RS04070 Protein ID WP_002916310.1
Coordinates 817329..817739 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KF986_RS04065 Protein ID WP_002916312.1
Coordinates 817082..817348 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF986_RS04040 (KF986_004040) 812238..813671 - 1434 WP_064145187.1 6-phospho-beta-glucosidase -
KF986_RS04045 (KF986_004045) 813790..814518 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KF986_RS04050 (KF986_004050) 814568..814879 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KF986_RS04055 (KF986_004055) 815043..815702 + 660 WP_002916317.1 hemolysin III family protein -
KF986_RS04060 (KF986_004060) 815853..816836 - 984 WP_064145188.1 tRNA-modifying protein YgfZ -
KF986_RS04065 (KF986_004065) 817082..817348 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KF986_RS04070 (KF986_004070) 817329..817739 + 411 WP_002916310.1 protein YgfX Toxin
KF986_RS04075 (KF986_004075) 817746..818267 - 522 WP_004144730.1 flavodoxin FldB -
KF986_RS04080 (KF986_004080) 818368..819264 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KF986_RS04085 (KF986_004085) 819287..820000 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KF986_RS04090 (KF986_004090) 820006..821739 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T240890 WP_002916310.1 NZ_CP094991:817329-817739 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T240890 NZ_LT838203:20567-20725 [Escherichia coli]
ATGAAACTGCCACGAAGTTCCCTTGTCTGGTGTGTGTTGATCGTGTGTCTCACACTGTTGATATTCACTTATCTGACACG
AAAATCGTTGTGCGAAATTCGTTACAGAGACGGATACAGGGAGGTGGCGGCTTTCCTGGCTTACGAATCCGGTAAGTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT240890 WP_002916312.1 NZ_CP094991:817082-817348 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT240890 NZ_LT838203:20367-20515 [Escherichia coli]
CAGGGTGCAGACATATGGGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGT
GTTGTGTGGCAGAAAGAAGATAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGCATCCCATATGTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References