Detailed information of TA system TA240855

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 5385074..5385690
• Replicon: chromosome
• Accession: NZ_CP094975
• Organism: Pseudomonas sp. PIA16

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: L9B60_RS24460
• Protein ID: WP_249673545.1
• Coordinates: 5385508..5385690 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: L9B60_RS24455
• Protein ID: WP_249673544.1
• Coordinates: 5385074..5385478 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L9B60_RS24440	5380209..5381471	-	1263	WP_249673541.1	arsenic transporter	-
L9B60_RS24445	5381484..5382728	-	1245	WP_249673542.1	MFS transporter	-
L9B60_RS24450	5382919..5385006	+	2088	WP_249673543.1	ATP-binding protein	-
L9B60_RS24455	5385074..5385478	-	405	WP_249673544.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
L9B60_RS24460	5385508..5385690	-	183	WP_249673545.1	type II toxin-antitoxin system HicA family toxin	Toxin
L9B60_RS24465	5385896..5386240	-	345	WP_249673546.1	hypothetical protein	-
L9B60_RS24470	5386467..5387840	-	1374	WP_249673547.1	aldehyde dehydrogenase family protein	-
L9B60_RS24475	5387947..5388825	+	879	WP_249673548.1	LysR family transcriptional regulator	-
L9B60_RS24480	5388847..5390253	-	1407	WP_249673549.1	DUF1173 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (3-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6767.06 Da
• Isoelectric Point: 11.7889

>T240855 WP_249673545.1 NZ_CP094975:c5385690-5385508 [Pseudomonas sp. PIA16]
VQSRQLIKELEMAGWVLKRVTGSHHIFKHPWHRASLPAPHPKKDLPLGTVKSIKARAGLL

Nucleotide

• Length: 183 bp

>T240855 NZ_LT838196:c2470277-2470101 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14579.59 Da
• Isoelectric Point: 4.4915

>AT240855 WP_249673544.1 NZ_CP094975:c5385478-5385074 [Pseudomonas sp. PIA16]
MQYPICIEWGDEGTAIGIQIPDIPGAVTAGDTFEDAYNAAIEVAHIMLEEIVADTGEVPMPTSAAQHRSHPDLANMGWGM
LEIDITPYLGKTEKVNVTLPGFVVKRIDRFVRDHSVKSRSSFLADAALEKLGRA

Nucleotide

• Length: 405 bp

>AT240855 NZ_LT838196:c2470055-2469639 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA