Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2688682..2690375 Replicon chromosome
Accession NZ_CP094975
Organism Pseudomonas sp. PIA16

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag L9B60_RS12090 Protein ID WP_249678920.1
Coordinates 2689506..2690375 (-) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag L9B60_RS12085 Protein ID WP_249678918.1
Coordinates 2688682..2689509 (-) Length 276 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L9B60_RS12065 2683887..2685383 - 1497 WP_249678911.1 aldehyde dehydrogenase -
L9B60_RS12070 2685394..2686197 - 804 WP_249678912.1 aspartate dehydrogenase -
L9B60_RS12075 2686208..2687890 - 1683 WP_249678914.1 thiamine pyrophosphate-binding protein -
L9B60_RS12080 2687883..2688680 - 798 WP_249678915.1 SDR family oxidoreductase -
L9B60_RS12085 2688682..2689509 - 828 WP_249678918.1 IclR family transcriptional regulator Antitoxin
L9B60_RS12090 2689506..2690375 - 870 WP_249678920.1 alpha/beta hydrolase Toxin
L9B60_RS12095 2690380..2690919 - 540 WP_249678922.1 cupin domain-containing protein -
L9B60_RS12100 2690933..2691694 - 762 WP_249678924.1 SDR family oxidoreductase -
L9B60_RS12105 2691694..2692470 - 777 WP_249678926.1 ABC transporter permease -
L9B60_RS12110 2692498..2693484 - 987 WP_249678928.1 ABC transporter substrate-binding protein -
L9B60_RS12115 2693523..2694374 - 852 WP_249678929.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-188)

Antitoxin

Transcription regulator IclR, C-terminal

(134-256)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30896.28 Da        Isoelectric Point: 7.1719

>T240852 WP_249678920.1 NZ_CP094975:c2690375-2689506 [Pseudomonas sp. PIA16]
MLNATENPTVALQGLLDSRFAQRTLKLDGCQQAVREAGDGPVIVLLHGIGSGAASWLEVALQLSQGARVIAWDAPGYGDS
TPLAPAAPTAEDYAARLLQTLDALNIERCVLVGHSLGAITAAAFSQLYPQRVNRLVLLSPARGYGDPARETQRLQVRAKR
LHSLETLGIPAMAEQRSSHMLSTRASAKALAWVRWNMARLNHQGYRQAIELLCGDDLLRHTPLSVPCEVHCGEADSITTP
ETCHSLAKALGVSFTLIPDAGHASPIEQPYVVAGRLAFAVQQSMTGSAQ

Download         Length: 870 bp

>T240852 NZ_LT838196:2009322-2009425 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 276 a.a.        Molecular weight: 30655.00 Da        Isoelectric Point: 6.4983

>AT240852 WP_249678918.1 NZ_CP094975:c2689509-2688682 [Pseudomonas sp. PIA16]
MNDSDLTKDAQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRTGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDKLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
DLRELYPEEHLERHSDCTPSTVLDLFDLVQKDRQRGFVSGEGFFESAISTVAAPVRDHTGGVVAALGVTIPTSQIGHVNF
EETLAQVRRSADELSRLLNYTPHQHHNRVTALMRD

Download         Length: 828 bp

>AT240852 NZ_LT838196:c2009463-2009192 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References