Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5201538..5203123 Replicon chromosome
Accession NZ_CP094943
Organism Dickeya dadantii strain FZ06

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MUB29_RS22965 Protein ID WP_263064153.1
Coordinates 5201804..5203123 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MUB29_RS22960 Protein ID WP_038924885.1
Coordinates 5201538..5201804 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB29_RS22935 5196836..5197447 - 612 WP_226054182.1 NAD(P)-dependent oxidoreductase -
MUB29_RS22940 5197590..5197970 + 381 WP_216284378.1 helix-turn-helix domain-containing protein -
MUB29_RS22945 5198095..5199180 - 1086 WP_263064150.1 4-hydroxyphenylpyruvate dioxygenase -
MUB29_RS22950 5199493..5200266 + 774 WP_263064151.1 MBL fold metallo-hydrolase -
MUB29_RS22955 5200311..5201288 + 978 WP_263064152.1 helix-turn-helix domain-containing protein -
MUB29_RS22960 5201538..5201804 + 267 WP_038924885.1 helix-turn-helix domain-containing protein Antitoxin
MUB29_RS22965 5201804..5203123 + 1320 WP_263064153.1 type II toxin-antitoxin system HipA family toxin Toxin
MUB29_RS22970 5203157..5204521 - 1365 WP_263064154.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
MUB29_RS22975 5204632..5206263 - 1632 WP_263064155.1 membrane protein insertase YidC -
MUB29_RS22980 5206266..5206523 - 258 WP_012886807.1 membrane protein insertion efficiency factor YidD -
MUB29_RS22985 5206487..5206846 - 360 WP_013320101.1 ribonuclease P protein component -
MUB29_RS22990 5206865..5207005 - 141 WP_004093983.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49379.70 Da        Isoelectric Point: 7.0579

>T240844 WP_263064153.1 NZ_CP094943:5201804-5203123 [Dickeya dadantii]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLAKVGQDSVGALQLVPQGTPARDIKQIEYKILSEQRLENILSGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDNHWCLPFNTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPYCFMIKAGKIKALAVERFDRK
YASDGSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSYLLGAVDPQRDRYSFMKAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRRETKLAMGLTGSRGKKYAIEQIFPRHFFQTAQAVGFARASMESILTEFAQSM
DAVMVNIRNQLPIDFPAPIRDSILEGMQARARRLMTGWE

Download         Length: 1320 bp

>T240844 NZ_LT838196:c608452-607988 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9899.23 Da        Isoelectric Point: 9.7281

>AT240844 WP_038924885.1 NZ_CP094943:5201538-5201804 [Dickeya dadantii]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNMDAANNEASV
APSWKEEW

Download         Length: 267 bp

>AT240844 NZ_LT838196:c608787-608452 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References