Detailed information of TA system TA240842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 3428072..3428625
• Replicon: chromosome
• Accession: NZ_CP094943
• Organism: Dickeya dadantii strain FZ06

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: MUB29_RS15055
• Protein ID: WP_263063200.1
• Coordinates: 3428072..3428386 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: MUB29_RS15060
• Protein ID: WP_263063201.1
• Coordinates: 3428389..3428625 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUB29_RS15035	3423454..3424470	+	1017	WP_171852177.1	P-type DNA transfer ATPase VirB11	-
MUB29_RS15040	3424511..3424813	+	303	WP_263063198.1	TrbM/KikA/MpfK family conjugal transfer protein	-
MUB29_RS15045	3425578..3427314	+	1737	WP_263066054.1	type IV secretion system DNA-binding domain-containing protein	-
MUB29_RS15050	3427323..3428075	+	753	WP_263063199.1	MobC family replication-relaxation protein	-
MUB29_RS15055	3428072..3428386	-	315	WP_263063200.1	CcdB family protein	Toxin
MUB29_RS15060	3428389..3428625	-	237	WP_263063201.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
MUB29_RS15065	3428946..3429890	-	945	WP_263063202.1	zincin-like metallopeptidase domain-containing protein	-
MUB29_RS15070	3430534..3431829	-	1296	WP_263063203.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	hcp	3393421..3442244	48823

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11458.35 Da
• Isoelectric Point: 7.9859

>T240842 WP_263063200.1 NZ_CP094943:c3428386-3428072 [Dickeya dadantii]
MQFTVYGNTGKSAVYPLLLDVTSDIIGQVNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRNQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T240842 NZ_LT827011:4273570-4273881 [Escherichia coli O127:H6]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9017.02 Da
• Isoelectric Point: 6.4798

>AT240842 WP_263063201.1 NZ_CP094943:c3428625-3428389 [Dickeya dadantii]
MTAKQRNTQSVTMTVERALLARAREAGINLSATLTTALDAELRHHEAKKWQEENREAIEALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT240842 NZ_LT827011:4273882-4274172 [Escherichia coli O127:H6]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG