Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1793092..1793645 Replicon chromosome
Accession NZ_CP094943
Organism Dickeya dadantii strain FZ06

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag MUB29_RS07955 Protein ID WP_119880390.1
Coordinates 1793331..1793645 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID C6CEY1
Locus tag MUB29_RS07950 Protein ID WP_012769207.1
Coordinates 1793092..1793328 (+) Length 79 a.a.

Genomic Context

MUB29_RS07935MUB29_RS07945MUB29_RS07950MUB29_RS07955MUB29_RS07940MUB29_RS07960MUB29_RS07965MUB29_RS07970
Location: 1788583..1789620 (1038 bp)
Type: Others
Protein ID: WP_263065056.1
Location: 1791828..1792772 (945 bp)
Type: Others
Protein ID: WP_263065058.1
Location: 1793092..1793328 (237 bp)
Type: Antitoxin
Protein ID: WP_012769207.1
Location: 1793331..1793645 (315 bp)
Type: Toxin
Protein ID: WP_119880390.1
Location: 1789590..1791449 (1860 bp)
Type: Others
Protein ID: WP_263065057.1
Location: 1793792..1793878 (87 bp)
Type: Others
Protein ID: Protein_1551
Location: 1794119..1795843 (1725 bp)
Type: Others
Protein ID: WP_263065059.1
Location: 1796431..1797177 (747 bp)
Type: Others
Protein ID: WP_263065060.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MUB29_RS079351788583..1789620+1038WP_263065056.1IS630 family transposase-
MUB29_RS079401789590..1791449-1860WP_263065057.1hypothetical protein-
MUB29_RS079451791828..1792772+945WP_263065058.1zincin-like metallopeptidase domain-containing protein-
MUB29_RS079501793092..1793328+237WP_012769207.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
MUB29_RS079551793331..1793645+315WP_119880390.1CcdB family proteinToxin
MUB29_RS079601793792..1793878-87Protein_1551mobilization protein mobC-
MUB29_RS079651794119..1795843-1725WP_263065059.1retron Ec67 family RNA-directed DNA polymerase/endonuclease-
MUB29_RS079701796431..1797177-747WP_263065060.1MobC family replication-relaxation protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideIntegrative and Conjugative Element-hcp / vgrG11784361..182748143120
-flankIS/Tn--1788583..17896201037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11496.46 Da        Isoelectric Point: 6.9727

>T240832 WP_119880390.1 NZ_CP094943:1793331-1793645 [Dickeya dadantii]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIEKYPAGRRPDRLVPVVMLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRSQVKAAIDFLIDGF

Download         Length: 315 bp

>T240832 NZ_LT827011:c1663217-1661895 [Escherichia coli O127:H6]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGCTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTATGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGGTCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9013.03 Da        Isoelectric Point: 6.4631

>AT240832 WP_012769207.1 NZ_CP094943:1793092-1793328 [Dickeya dadantii]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRRHEAKKWQEENREAIDALNRFHDENGCFSDEYRTF

Download         Length: 237 bp

>AT240832 NZ_LT827011:c1663483-1663217 [Escherichia coli O127:H6]
ATGATGAGCTTTCAGAAGATCTATAGCCCAATGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCAAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7W2E4H0

References