Detailed information of TA system TA240831

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1332256..1332881
• Replicon: chromosome
• Accession: NZ_CP094943
• Organism: Dickeya dadantii strain FZ06

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: E0SD87
• Locus tag: MUB29_RS06060
• Protein ID: WP_009114000.1
• Coordinates: 1332256..1332459 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: MUB29_RS06065
• Protein ID: WP_038922044.1
• Coordinates: 1332513..1332881 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUB29_RS06030	1327914..1328252	+	339	WP_002208627.1	P-II family nitrogen regulator	-
MUB29_RS06035	1328295..1329587	+	1293	WP_216282074.1	ammonium transporter AmtB	-
MUB29_RS06040	1329682..1330545	-	864	WP_263064855.1	acyl-CoA thioesterase II	-
MUB29_RS06045	1330780..1331337	+	558	WP_226054005.1	YbaY family lipoprotein	-
MUB29_RS06050	1331374..1331697	-	324	WP_263064856.1	MGMT family protein	-
MUB29_RS06060	1332256..1332459	-	204	WP_009114000.1	HHA domain-containing protein	Toxin
MUB29_RS06065	1332513..1332881	-	369	WP_038922044.1	Hha toxicity modulator TomB	Antitoxin
MUB29_RS06070	1333388..1333531	-	144	WP_216282079.1	type B 50S ribosomal protein L36	-
MUB29_RS06075	1333547..1333798	-	252	WP_013316872.1	type B 50S ribosomal protein L31	-
MUB29_RS06080	1333979..1337125	-	3147	WP_226054007.1	efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8133.51 Da
• Isoelectric Point: 8.8500

>T240831 WP_009114000.1 NZ_CP094943:c1332459-1332256 [Dickeya dadantii]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Nucleotide

• Length: 204 bp

>T240831 NZ_LT827011:c1621795-1621517 [Escherichia coli O127:H6]
ATGATAATGAATTTCAGACACAAGGGATTGCGTGACTTGTTTCTTCTCGGCAAAACCTCCGGCGTTATACCGACGCAAGT
CAAACGATTACGCCACCGACTCGCTGTGATTGATGCAGCATGCTGTCTTGCTGATATCGATATGCCCGGTTACCGACTAC
ATCCGTTAAGCGGCGATCGCGATGGAATTTGGGCGATATCTGTCTCGGGCAACTGGCGAATCACATTTGAATTCGTCAAT
GGCGATGCATACATACTGGATTACGAGGACTATCACTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14270.12 Da
• Isoelectric Point: 5.1811

>AT240831 WP_038922044.1 NZ_CP094943:c1332881-1332513 [Dickeya dadantii]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSRGWVNDPTSAVNLQLNELIEHIAAFVVTYKIKYPHEAALCERVEKYL
DDTYILFSNYGINDTELRKWQKSRSQLFRMFSEKSICTVVKT

Nucleotide

• Length: 369 bp

>AT240831 NZ_LT827011:c1621517-1621233 [Escherichia coli O127:H6]
ATGAAAATGGCCAATCATCCCCGCCCGGGGGACATTATTCTGGAATCACTGGACGAACTTAATGTCAGCCTGCGCGAGTT
TGCCAGAGCAATGGAAATTGCGCCCTCAACGGCAAGCCGATTGCTGACCGGAAAAGCAGCTTTGACGCCAGAAATGGCAA
TAAAACTGTCCGTGGTGATCGGCAGTTCGCCGCAAATGTGGCTGAATCTGCAAAATGCCTGGAGTCTGGCAGAGGCGGAA
AAAACGGTGGATGTGTCGCGACTGCGCCGTCTGGTTACGCAATAA

Structures

Toxin

• AlphaFold DB: A0A1X3RNQ0