Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-UPF0150 |
| Location | 611817..612469 | Replicon | chromosome |
| Accession | NZ_CP094942 | ||
| Organism | [Clostridium] innocuum strain VE303-07 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | A0A099IA21 |
| Locus tag | K5I27_RS03180 | Protein ID | WP_008727647.1 |
| Coordinates | 612275..612469 (-) | Length | 65 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | K5I27_RS03175 | Protein ID | WP_100933708.1 |
| Coordinates | 611817..612221 (-) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K5I27_RS03145 (K5I27_03145) | 608119..608832 | + | 714 | WP_242411035.1 | collagen-like protein | - |
| K5I27_RS03150 (K5I27_03150) | 608845..609888 | + | 1044 | WP_247230588.1 | hypothetical protein | - |
| K5I27_RS03155 (K5I27_03155) | 609901..610233 | + | 333 | WP_008727640.1 | hypothetical protein | - |
| K5I27_RS03160 (K5I27_03160) | 610230..610352 | + | 123 | WP_002607678.1 | XkdX family protein | - |
| K5I27_RS03165 (K5I27_03165) | 610441..610896 | + | 456 | WP_002607677.1 | phage holin family protein | - |
| K5I27_RS03170 (K5I27_03170) | 610896..611759 | + | 864 | WP_008727644.1 | hypothetical protein | - |
| K5I27_RS03175 (K5I27_03175) | 611817..612221 | - | 405 | WP_100933708.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| K5I27_RS03180 (K5I27_03180) | 612275..612469 | - | 195 | WP_008727647.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| K5I27_RS03185 (K5I27_03185) | 613370..613804 | + | 435 | WP_008818762.1 | thioredoxin fold domain-containing protein | - |
| K5I27_RS03190 (K5I27_03190) | 613774..614583 | + | 810 | WP_008818763.1 | AAC(3) family N-acetyltransferase | - |
| K5I27_RS03195 (K5I27_03195) | 614571..615023 | - | 453 | WP_008818764.1 | GAF domain-containing protein | - |
| K5I27_RS03200 (K5I27_03200) | 615217..615498 | - | 282 | WP_008818765.1 | spore coat protein | - |
| K5I27_RS03205 (K5I27_03205) | 615500..615691 | - | 192 | WP_009271079.1 | hypothetical protein | - |
| K5I27_RS03210 (K5I27_03210) | 615825..616370 | + | 546 | WP_002607666.1 | DUF402 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 576538..614583 | 38045 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7266.59 Da Isoelectric Point: 10.6607
>T240829 WP_008727647.1 NZ_CP094942:c612469-612275 [[Clostridium] innocuum]
MPMTAKQMIKYLKQNGFQEVPGGGGSHRKFYNPDTRKTTIVPYHCKDLKKGMEQAILKQAGLKK
MPMTAKQMIKYLKQNGFQEVPGGGGSHRKFYNPDTRKTTIVPYHCKDLKKGMEQAILKQAGLKK
Download Length: 195 bp
>T240829 NZ_LT827011:c1225087-1224593 [Escherichia coli O127:H6]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGTATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGTATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG
Antitoxin
Download Length: 135 a.a. Molecular weight: 15155.13 Da Isoelectric Point: 4.3331
>AT240829 WP_100933708.1 NZ_CP094942:c612221-611817 [[Clostridium] innocuum]
MSKLYYPAVFHEAEPDETGYWVEFPDLPGCLTQGETLEEAAEMAEDALGTWFAPNSLEPAQEFPKPSNPSDIKLQGRDFV
LMVKYDGVEWAKRYNNKAVKKTLTIPAWLNDLADKNNINYSQTLQDALIKKLGI
MSKLYYPAVFHEAEPDETGYWVEFPDLPGCLTQGETLEEAAEMAEDALGTWFAPNSLEPAQEFPKPSNPSDIKLQGRDFV
LMVKYDGVEWAKRYNNKAVKKTLTIPAWLNDLADKNNINYSQTLQDALIKKLGI
Download Length: 405 bp
>AT240829 NZ_LT827011:c1225377-1225084 [Escherichia coli O127:H6]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|