240824

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4767418..4767934 Replicon chromosome
Accession NZ_CP094940
Organism Klebsiella pneumoniae strain FK1979

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag MUB43_RS23095 Protein ID WP_004178374.1
Coordinates 4767418..4767702 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag MUB43_RS23100 Protein ID WP_002886901.1
Coordinates 4767692..4767934 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB43_RS23070 (4762901) 4762901..4763164 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
MUB43_RS23075 (4763294) 4763294..4763467 + 174 WP_004210630.1 hypothetical protein -
MUB43_RS23080 (4763470) 4763470..4764213 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MUB43_RS23085 (4764570) 4764570..4766708 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MUB43_RS23090 (4766950) 4766950..4767414 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MUB43_RS23095 (4767418) 4767418..4767702 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUB43_RS23100 (4767692) 4767692..4767934 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MUB43_RS23105 (4768012) 4768012..4769922 - 1911 WP_004152270.1 PRD domain-containing protein -
MUB43_RS23110 (4769945) 4769945..4771099 - 1155 WP_004210635.1 lactonase family protein -
MUB43_RS23115 (4771166) 4771166..4771906 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T240824 WP_004178374.1 NZ_CP094940:c4767702-4767418 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T240824 NZ_LT827010:c1529289-1529032 [Actinoplanes sp. SE50/110]
GTGACTTCAGCGATCAGTGCCAGCGAGGCTCGCAAGTCCCTCTTTCCGCTCATCGAACGAGTCAACCTGGACCACACTCC
GATCGAAATCGTCTCCAAGCGCGGCAACGCCGTCCTGGTGAGCAAGGAGGACTGGGACTCGATCATGGAAACCAACTACC
TGCTTCGATCCCCCGCCAACGCCAAGCGCCTCACTGAGAGCGTCGAGCAATGGCGAGCGGGACGAGCCACGGAGCGCGAG
TTCGGCCCCGAGGAGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT240824 WP_002886901.1 NZ_CP094940:c4767934-4767692 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT240824 NZ_LT827010:c1529035-1528775 [Actinoplanes sp. SE50/110]
GTGAAACTCAGCTGGACCGACCACGCCTGGGACGACTACCTGTACCGGCAGACTCAGGACCGCAGAACCCTCAAACGCAT
CAACGCCCTGATCGCCGACATCAAACGTGATCCCGACGGTCAGGGCATCGGCAAACCGGAGATCCTCCGAAACAACCTCG
CGGGACTCCGGTCCCGGCGCATCGACGACGAACACCGCATGGTGTACGCCGTCGAGACCAACGAGATCACCATCATCTCC
TGCCGATACCATCACGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References