Detailed information of TA system TA240823

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 4704856..4706193
• Replicon: chromosome
• Accession: NZ_CP094940
• Organism: Klebsiella pneumoniae strain FK1979

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: MUB43_RS22830
• Protein ID: WP_032424556.1
• Coordinates: 4705258..4706193 (+)
• Length: 312 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: MUB43_RS22825
• Protein ID: WP_023302769.1
• Coordinates: 4704856..4705251 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUB43_RS22795 (4700100)	4700100..4700390	+	291	WP_022615704.1	hypothetical protein	-
MUB43_RS22800 (4700455)	4700455..4701360	+	906	WP_022615703.1	zincin-like metallopeptidase domain-containing protein	-
MUB43_RS22805 (4701553)	4701553..4701924	+	372	WP_022615702.1	hypothetical protein	-
MUB43_RS22810 (4702098)	4702098..4703693	+	1596	WP_023302771.1	MobH family relaxase	-
MUB43_RS22815 (4703865)	4703865..4704329	+	465	WP_022615700.1	GNAT family N-acetyltransferase	-
MUB43_RS22820 (4704335)	4704335..4704601	-	267	WP_023302770.1	hypothetical protein	-
MUB43_RS22825 (4704856)	4704856..4705251	+	396	WP_023302769.1	DUF6088 family protein	Antitoxin
MUB43_RS22830 (4705258)	4705258..4706193	+	936	WP_032424556.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MUB43_RS22835 (4706201)	4706201..4706890	-	690	WP_023302767.1	abortive infection system antitoxin AbiGi family protein	-
MUB43_RS22840 (4707095)	4707095..4707787	-	693	WP_223272586.1	RES family NAD+ phosphorylase	-
MUB43_RS22845 (4708308)	4708308..4709987	-	1680	WP_004212561.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-298)

Antitoxin

• Protein of unknown function DUF6088 (7-109)

Sequences

Toxin

Protein

• Length: 312 a.a.
• Molecular weight: 35389.66 Da
• Isoelectric Point: 5.6165

>T240823 WP_032424556.1 NZ_CP094940:4705258-4706193 [Klebsiella pneumoniae]
MLFSDVTDALGIESGAIVEKDHYIVELLHLLKPLTFDTHQLLFAGGTALAKSGIVLNRMSEDVDIKLVPTDTFLSLSRTQ
RKGIRKEIVQTISHAITATDMFSFDDAHPKVTRDEYRYNDIPVRYPQRVAQAPCLRPFIQLELMEANLLEAPEFRDIHTL
VTTLTGKAPVISAFPCATIISTQAEKLVAMLRRTAAVARNIERQDDASLVRHIYDTYCIVQAGNVDMCLLTDFFKQTIEQ
DIQRYGNQYPQFCVSPNDELKMGLDELEHNPLYKTRYQQFVAPMVYGARKVSWDEAYASFRQMALIILDTY

Nucleotide

• Length: 936 bp

>T240823 NZ_LT827010:c1529035-1528775 [Actinoplanes sp. SE50/110]
GTGAAACTCAGCTGGACCGACCACGCCTGGGACGACTACCTGTACCGGCAGACTCAGGACCGCAGAACCCTCAAACGCAT
CAACGCCCTGATCGCCGACATCAAACGTGATCCCGACGGTCAGGGCATCGGCAAACCGGAGATCCTCCGAAACAACCTCG
CGGGACTCCGGTCCCGGCGCATCGACGACGAACACCGCATGGTGTACGCCGTCGAGACCAACGAGATCACCATCATCTCC
TGCCGATACCATCACGAATAG

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14800.08 Da
• Isoelectric Point: 11.1078

>AT240823 WP_023302769.1 NZ_CP094940:4704856-4705251 [Klebsiella pneumoniae]
MTIKTRIQSRLKRSKRYVFTRDDFKDIAGYDQIGRVLRDLLKEGQLLKVGYGVYTKARRNSITGKVMPAAPRGSSAVIVE
TLERLKVRYRYEGATQTYNSGESTQIPVSPEIKTSPRFKRALSVGNSKLNG

Nucleotide

• Length: 396 bp

>AT240823 NZ_LT827010:c1529289-1529032 [Actinoplanes sp. SE50/110]
GTGACTTCAGCGATCAGTGCCAGCGAGGCTCGCAAGTCCCTCTTTCCGCTCATCGAACGAGTCAACCTGGACCACACTCC
GATCGAAATCGTCTCCAAGCGCGGCAACGCCGTCCTGGTGAGCAAGGAGGACTGGGACTCGATCATGGAAACCAACTACC
TGCTTCGATCCCCCGCCAACGCCAAGCGCCTCACTGAGAGCGTCGAGCAATGGCGAGCGGGACGAGCCACGGAGCGCGAG
TTCGGCCCCGAGGAGTGA