Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4043934..4044553 Replicon chromosome
Accession NZ_CP094940
Organism Klebsiella pneumoniae strain FK1979

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MUB43_RS19670 Protein ID WP_002892050.1
Coordinates 4044335..4044553 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MUB43_RS19665 Protein ID WP_002892066.1
Coordinates 4043934..4044308 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB43_RS19655 (4039086) 4039086..4040279 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MUB43_RS19660 (4040302) 4040302..4043448 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MUB43_RS19665 (4043934) 4043934..4044308 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MUB43_RS19670 (4044335) 4044335..4044553 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MUB43_RS19675 (4044712) 4044712..4045278 + 567 WP_002892030.1 maltose O-acetyltransferase -
MUB43_RS19680 (4045250) 4045250..4045390 - 141 WP_004147370.1 hypothetical protein -
MUB43_RS19685 (4045411) 4045411..4045881 + 471 WP_002892026.1 YlaC family protein -
MUB43_RS19690 (4045856) 4045856..4047307 - 1452 WP_004213726.1 PLP-dependent aminotransferase family protein -
MUB43_RS19695 (4047408) 4047408..4048106 + 699 WP_004177238.1 GNAT family protein -
MUB43_RS19700 (4048103) 4048103..4048243 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MUB43_RS19705 (4048243) 4048243..4048506 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T240821 WP_002892050.1 NZ_CP094940:4044335-4044553 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T240821 NZ_LT795507:c15159-14911 [Escherichia coli]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT240821 WP_002892066.1 NZ_CP094940:4043934-4044308 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT240821 NZ_LT795507:c14914-14567 [Escherichia coli]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGGAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCACTGAACGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References