Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | pemIK/PRK09812-MazE |
Location | 1827796..1828386 | Replicon | chromosome |
Accession | NZ_CP094940 | ||
Organism | Klebsiella pneumoniae strain FK1979 |
Toxin (Protein)
Gene name | pemK | Uniprot ID | A0A2L1BXX2 |
Locus tag | MUB43_RS08890 | Protein ID | WP_022615588.1 |
Coordinates | 1828054..1828386 (+) | Length | 111 a.a. |
Antitoxin (Protein)
Gene name | pemI | Uniprot ID | A0A3S7DDD0 |
Locus tag | MUB43_RS08885 | Protein ID | WP_000288812.1 |
Coordinates | 1827796..1828053 (+) | Length | 86 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
MUB43_RS08860 (1823704) | 1823704..1823781 | + | 78 | Protein_1737 | type II toxin-antitoxin system PemK/MazF family toxin | - |
MUB43_RS08865 (1824131) | 1824131..1825879 | + | 1749 | WP_032457402.1 | hypothetical protein | - |
MUB43_RS08870 (1825958) | 1825958..1826514 | + | 557 | Protein_1739 | hypothetical protein | - |
MUB43_RS08875 (1826797) | 1826797..1827258 | + | 462 | WP_004213450.1 | hypothetical protein | - |
MUB43_RS08880 (1827255) | 1827255..1827461 | + | 207 | WP_022615589.1 | helix-turn-helix transcriptional regulator | - |
MUB43_RS08885 (1827796) | 1827796..1828053 | + | 258 | WP_000288812.1 | antitoxin | Antitoxin |
MUB43_RS08890 (1828054) | 1828054..1828386 | + | 333 | WP_022615588.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
MUB43_RS08900 (1828708) | 1828708..1830144 | + | 1437 | WP_004151469.1 | EmmdR/YeeO family multidrug/toxin efflux MATE transporter | - |
MUB43_RS08910 (1830510) | 1830510..1831964 | - | 1455 | WP_004148975.1 | AMP nucleosidase | - |
MUB43_RS08915 (1832094) | 1832094..1832339 | - | 246 | WP_004141189.1 | signal transduction protein PmrD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 11913.80 Da Isoelectric Point: 10.1839
>T240811 WP_022615588.1 NZ_CP094940:1828054-1828386 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS
Download Length: 333 bp
>T240811 NZ_LT795502:2788522-2788629 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9442.92 Da Isoelectric Point: 4.3566
>AT240811 WP_000288812.1 NZ_CP094940:1827796-1828053 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL
Download Length: 258 bp
>AT240811 NZ_LT795502:c2788469-2788408 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2L1BXX2 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A3S7DDD0 |