Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1827796..1828386 Replicon chromosome
Accession NZ_CP094940
Organism Klebsiella pneumoniae strain FK1979

Toxin (Protein)


Gene name pemK Uniprot ID A0A2L1BXX2
Locus tag MUB43_RS08890 Protein ID WP_022615588.1
Coordinates 1828054..1828386 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag MUB43_RS08885 Protein ID WP_000288812.1
Coordinates 1827796..1828053 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB43_RS08860 (1823704) 1823704..1823781 + 78 Protein_1737 type II toxin-antitoxin system PemK/MazF family toxin -
MUB43_RS08865 (1824131) 1824131..1825879 + 1749 WP_032457402.1 hypothetical protein -
MUB43_RS08870 (1825958) 1825958..1826514 + 557 Protein_1739 hypothetical protein -
MUB43_RS08875 (1826797) 1826797..1827258 + 462 WP_004213450.1 hypothetical protein -
MUB43_RS08880 (1827255) 1827255..1827461 + 207 WP_022615589.1 helix-turn-helix transcriptional regulator -
MUB43_RS08885 (1827796) 1827796..1828053 + 258 WP_000288812.1 antitoxin Antitoxin
MUB43_RS08890 (1828054) 1828054..1828386 + 333 WP_022615588.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUB43_RS08900 (1828708) 1828708..1830144 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
MUB43_RS08910 (1830510) 1830510..1831964 - 1455 WP_004148975.1 AMP nucleosidase -
MUB43_RS08915 (1832094) 1832094..1832339 - 246 WP_004141189.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11913.80 Da        Isoelectric Point: 10.1839

>T240811 WP_022615588.1 NZ_CP094940:1828054-1828386 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

>T240811 NZ_LT795502:2788522-2788629 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT240811 WP_000288812.1 NZ_CP094940:1827796-1828053 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp

>AT240811 NZ_LT795502:c2788469-2788408 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1BXX2

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References