Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 798058..798715 Replicon chromosome
Accession NZ_CP094940
Organism Klebsiella pneumoniae strain FK1979

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag MUB43_RS03945 Protein ID WP_002916310.1
Coordinates 798305..798715 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag MUB43_RS03940 Protein ID WP_002916312.1
Coordinates 798058..798324 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUB43_RS03915 (793215) 793215..794648 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
MUB43_RS03920 (794767) 794767..795495 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
MUB43_RS03925 (795544) 795544..795855 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
MUB43_RS03930 (796019) 796019..796678 + 660 WP_002916317.1 hemolysin III family protein -
MUB43_RS03935 (796829) 796829..797812 - 984 WP_022615657.1 tRNA-modifying protein YgfZ -
MUB43_RS03940 (798058) 798058..798324 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
MUB43_RS03945 (798305) 798305..798715 + 411 WP_002916310.1 protein YgfX Toxin
MUB43_RS03950 (798722) 798722..799243 - 522 WP_002916308.1 flavodoxin FldB -
MUB43_RS03955 (799344) 799344..800240 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
MUB43_RS03960 (800263) 800263..800976 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MUB43_RS03965 (800982) 800982..802715 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T240810 WP_002916310.1 NZ_CP094940:798305-798715 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T240810 NZ_LT795502:2787986-2788093 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGAGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT240810 WP_002916312.1 NZ_CP094940:798058-798324 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT240810 NZ_LT795502:c2787939-2787873 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References