Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-RHH
Location 831751..832238 Replicon chromosome
Accession NZ_CP094929
Organism Sphaerochaeta associata strain GLS2T

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MUG09_RS03840 Protein ID WP_244773757.1
Coordinates 831969..832238 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MUG09_RS03835 Protein ID WP_244773756.1
Coordinates 831751..831972 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUG09_RS03800 (MUG09_03800) 827664..828023 - 360 WP_244773748.1 NifB/NifX family molybdenum-iron cluster-binding protein -
MUG09_RS03805 (MUG09_03805) 828049..828873 - 825 WP_244773750.1 MBL fold metallo-hydrolase -
MUG09_RS03810 (MUG09_03810) 828870..829745 - 876 WP_244773751.1 ATP-binding protein -
MUG09_RS03815 (MUG09_03815) 829717..830589 - 873 WP_244773752.1 ATP-binding protein -
MUG09_RS03820 (MUG09_03820) 830564..830926 - 363 WP_244773753.1 NifB/NifX family molybdenum-iron cluster-binding protein -
MUG09_RS03825 (MUG09_03825) 830923..831303 - 381 WP_244773754.1 DUF134 domain-containing protein -
MUG09_RS03830 (MUG09_03830) 831300..831521 - 222 WP_244773755.1 DUF5320 domain-containing protein -
MUG09_RS03835 (MUG09_03835) 831751..831972 + 222 WP_244773756.1 DUF6290 family protein Antitoxin
MUG09_RS03840 (MUG09_03840) 831969..832238 + 270 WP_244773757.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUG09_RS03845 (MUG09_03845) 832248..832925 - 678 WP_244773758.1 hypothetical protein -
MUG09_RS03850 (MUG09_03850) 832986..834257 - 1272 WP_244773759.1 adenylosuccinate synthase -
MUG09_RS03855 (MUG09_03855) 834257..834814 - 558 WP_244773760.1 phosphoribosyltransferase -
MUG09_RS03860 (MUG09_03860) 834825..835382 - 558 WP_244773761.1 hypoxanthine phosphoribosyltransferase -
MUG09_RS03865 (MUG09_03865) 835570..836085 + 516 WP_244773762.1 flavin reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Protein of unknown function DUF6290

(3-70)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10585.28 Da        Isoelectric Point: 9.7317

>T240805 WP_244773757.1 NZ_CP094929:831969-832238 [Sphaerochaeta associata]
MKYHVEFSNDARKTLKKMDKHISLMLVAWIRKHLEDCTNPYQSGKSLTADRSGQWRYRIGDYRLIAEILEDRVVILILHV
GHRIDVYTQ

Download         Length: 270 bp

>T240805 NZ_LT795502:1865525-1865779 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8581.74 Da        Isoelectric Point: 4.1831

>AT240805 WP_244773756.1 NZ_CP094929:831751-831972 [Sphaerochaeta associata]
MGLSVRLKQDELELIQRYAELKGLTISELVRQSILERIEDEFDLKLYEKAISEFHNNPVTYSLDEIEQELGLQ

Download         Length: 222 bp

>AT240805 NZ_LT795502:1865277-1865528 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References