Detailed information of TA system TA240804

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 774343..774889
• Replicon: chromosome
• Accession: NZ_CP094929
• Organism: Sphaerochaeta associata strain GLS2T

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MUG09_RS03540
• Protein ID: WP_244773621.1
• Coordinates: 774611..774889 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MUG09_RS03535
• Protein ID: WP_244773620.1
• Coordinates: 774343..774618 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUG09_RS03505 (MUG09_03505)	769615..770268	-	654	WP_244773613.1	amino acid ABC transporter permease	-
MUG09_RS03510 (MUG09_03510)	770341..771138	-	798	WP_244773616.1	transporter substrate-binding domain-containing protein	-
MUG09_RS03515 (MUG09_03515)	771185..771922	-	738	WP_280529404.1	amino acid ABC transporter ATP-binding protein	-
MUG09_RS03520 (MUG09_03520)	772390..772983	-	594	WP_244773617.1	hypothetical protein	-
MUG09_RS03525 (MUG09_03525)	773427..773786	+	360	WP_244773618.1	type II toxin-antitoxin system RelE/ParE family toxin	-
MUG09_RS03530 (MUG09_03530)	773783..774091	+	309	WP_244773619.1	transcriptional regulator	-
MUG09_RS03535 (MUG09_03535)	774343..774618	+	276	WP_244773620.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
MUG09_RS03540 (MUG09_03540)	774611..774889	+	279	WP_244773621.1	type II toxin-antitoxin system YafQ family toxin	Toxin
MUG09_RS03545 (MUG09_03545)	775239..776003	+	765	WP_244773622.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
MUG09_RS03550 (MUG09_03550)	775978..776895	+	918	WP_244773624.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
MUG09_RS03555 (MUG09_03555)	777185..777619	-	435	WP_244773625.1	nucleotidyltransferase substrate binding protein	-
MUG09_RS03560 (MUG09_03560)	779212..779616	-	405	WP_244775357.1	sugar phosphate nucleotidyltransferase	-
MUG09_RS03565 (MUG09_03565)	779548..779709	+	162	WP_244773627.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (3-92)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-89)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10760.64 Da
• Isoelectric Point: 9.1484

>T240804 WP_244773621.1 NZ_CP094929:774611-774889 [Sphaerochaeta associata]
MLKLEFTGQFKKDYKLAIKRGCNPSKLEQVITLLCNEQPLPEVYRDHALVNSRNYTGMRECHIQPDWLLVYKVVQQALIL
KLIRTGTHSDLF

Nucleotide

• Length: 279 bp

>T240804 NZ_LT795502:1865277-1865528 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAATGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9957.37 Da
• Isoelectric Point: 4.5049

>AT240804 WP_244773620.1 NZ_CP094929:774343-774618 [Sphaerochaeta associata]
MAGKADTSMTIRMNRDVKQQAQQIFSDLGMDMSTAINIFLRQAISFKGLPFEVALHTPNEVTLAAMDAAEHDKDMHGPFE
SVASLMDALDA

Nucleotide

• Length: 276 bp

>AT240804 NZ_LT795502:1865525-1865779 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA