Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 215927..217473 Replicon chromosome
Accession NZ_CP094929
Organism Sphaerochaeta associata strain GLS2T

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MUG09_RS00995 Protein ID WP_244772719.1
Coordinates 216169..217473 (+) Length 435 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MUG09_RS00990 Protein ID WP_244772718.1
Coordinates 215927..216172 (+) Length 82 a.a.

Genomic Context

MUG09_RS00965MUG09_RS00975MUG09_RS00980MUG09_RS00985MUG09_RS00990MUG09_RS00995MUG09_RS01005MUG09_RS01010MUG09_RS01015MUG09_RS00970MUG09_RS01000
Location: 210981..212489 (1509 bp)
Type: Others
Protein ID: WP_244772713.1
Location: 213202..214539 (1338 bp)
Type: Others
Protein ID: WP_244772715.1
Location: 214714..215484 (771 bp)
Type: Others
Protein ID: WP_244772716.1
Location: 215562..215858 (297 bp)
Type: Others
Protein ID: WP_244772717.1
Location: 215927..216172 (246 bp)
Type: Antitoxin
Protein ID: WP_244772718.1
Location: 216169..217473 (1305 bp)
Type: Toxin
Protein ID: WP_244772719.1
Location: 219151..219915 (765 bp)
Type: Others
Protein ID: WP_244772721.1
Location: 219927..221186 (1260 bp)
Type: Others
Protein ID: WP_244772722.1
Location: 221170..222384 (1215 bp)
Type: Others
Protein ID: WP_244772723.1
Location: 212614..212904 (291 bp)
Type: Others
Protein ID: WP_244772714.1
Location: 217470..219017 (1548 bp)
Type: Others
Protein ID: WP_244772720.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MUG09_RS00965 (MUG09_00965)210981..212489+1509WP_244772713.1galactarate dehydratase-
MUG09_RS00970 (MUG09_00970)212614..212904-291WP_244772714.1hypothetical protein-
MUG09_RS00975 (MUG09_00975)213202..214539+1338WP_244772715.1ATP-binding protein-
MUG09_RS00980 (MUG09_00980)214714..215484+771WP_244772716.1putative DNA binding domain-containing protein-
MUG09_RS00985 (MUG09_00985)215562..215858+297WP_244772717.1hypothetical protein-
MUG09_RS00990 (MUG09_00990)215927..216172+246WP_244772718.1helix-turn-helix transcriptional regulatorAntitoxin
MUG09_RS00995 (MUG09_00995)216169..217473+1305WP_244772719.1type II toxin-antitoxin system HipA family toxinToxin
MUG09_RS01000 (MUG09_01000)217470..219017-1548WP_244772720.1DEAD/DEAH box helicase-
MUG09_RS01005 (MUG09_01005)219151..219915+765WP_244772721.1hypothetical protein-
MUG09_RS01010 (MUG09_01010)219927..221186+1260WP_244772722.1DUF2791 family P-loop domain-containing protein-
MUG09_RS01015 (MUG09_01015)221170..222384+1215WP_244772723.1DUF2791 family P-loop domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-397)

Antitoxin

Cro/C1-type helix-turn-helix domain

(15-66)


Sequences

Toxin        


Download         Length: 435 a.a.        Molecular weight: 49226.19 Da        Isoelectric Point: 6.6121

>T240803 WP_244772719.1 NZ_CP094929:216169-217473 [Sphaerochaeta associata]
MRTQTTLDVWMNGTFVGRWSRDKGVHTFEYDVSYVQNPNACPLSLSLPLYQTSVGTFVESFFDNLLPDSFEIRRRLARRF
GCASDSAFDILAETGRDCVGALQILKKDSPIPSVRTVEKQALTEHEIELLLLDAVSNNPISVNNDDFFRISLAGAQEKTA
LLFHDGSWCMSLGATPSTHIIKLPIRAMNSLSLDLHNSVENEWLCLQILQAFGLPVAQADMHDFGNQRVLVVKRFDRKLS
GDGSWYVRIPQEDFCQAHGLPSSRKYEVDKGVGIQACMDLLQASSQAYGDRKTFLSAHFLYWLMAAPDAHAKNFSLYLEQ
QGRFRMTPLYDVLSLHPVIEQGKGQIFDRKVTLAMGLERRAHRYGWSTMQRQHWLDTAKLCGAEHIMQTIMDETLHDLPQ
VLERLESQLPQDFPQDVAQPIFNGMRKAALRLQS

Download         Length: 1305 bp

>T240803 NZ_LT795502:1345381-1345779 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9102.63 Da        Isoelectric Point: 8.0097

>AT240803 WP_244772718.1 NZ_CP094929:215927-216172 [Sphaerochaeta associata]
MQYPIQTPVQLGSYLRTRRKALGLTQKEAALRIGLLPKTISALENDPLHCSIESLLRLLSALNLEFLLQGKEDAPQGNMW
E

Download         Length: 246 bp

>AT240803 NZ_LT795502:1345154-1345381 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References