Detailed information of TA system TA240803

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 215927..217473
• Replicon: chromosome
• Accession: NZ_CP094929
• Organism: Sphaerochaeta associata strain GLS2T

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MUG09_RS00995
• Protein ID: WP_244772719.1
• Coordinates: 216169..217473 (+)
• Length: 435 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MUG09_RS00990
• Protein ID: WP_244772718.1
• Coordinates: 215927..216172 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUG09_RS00965 (MUG09_00965)	210981..212489	+	1509	WP_244772713.1	galactarate dehydratase	-
MUG09_RS00970 (MUG09_00970)	212614..212904	-	291	WP_244772714.1	hypothetical protein	-
MUG09_RS00975 (MUG09_00975)	213202..214539	+	1338	WP_244772715.1	ATP-binding protein	-
MUG09_RS00980 (MUG09_00980)	214714..215484	+	771	WP_244772716.1	putative DNA binding domain-containing protein	-
MUG09_RS00985 (MUG09_00985)	215562..215858	+	297	WP_244772717.1	hypothetical protein	-
MUG09_RS00990 (MUG09_00990)	215927..216172	+	246	WP_244772718.1	helix-turn-helix transcriptional regulator	Antitoxin
MUG09_RS00995 (MUG09_00995)	216169..217473	+	1305	WP_244772719.1	type II toxin-antitoxin system HipA family toxin	Toxin
MUG09_RS01000 (MUG09_01000)	217470..219017	-	1548	WP_244772720.1	DEAD/DEAH box helicase	-
MUG09_RS01005 (MUG09_01005)	219151..219915	+	765	WP_244772721.1	hypothetical protein	-
MUG09_RS01010 (MUG09_01010)	219927..221186	+	1260	WP_244772722.1	DUF2791 family P-loop domain-containing protein	-
MUG09_RS01015 (MUG09_01015)	221170..222384	+	1215	WP_244772723.1	DUF2791 family P-loop domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-397)

Antitoxin

• Cro/C1-type helix-turn-helix domain (15-66)

Sequences

Toxin

Protein

• Length: 435 a.a.
• Molecular weight: 49226.19 Da
• Isoelectric Point: 6.6121

>T240803 WP_244772719.1 NZ_CP094929:216169-217473 [Sphaerochaeta associata]
MRTQTTLDVWMNGTFVGRWSRDKGVHTFEYDVSYVQNPNACPLSLSLPLYQTSVGTFVESFFDNLLPDSFEIRRRLARRF
GCASDSAFDILAETGRDCVGALQILKKDSPIPSVRTVEKQALTEHEIELLLLDAVSNNPISVNNDDFFRISLAGAQEKTA
LLFHDGSWCMSLGATPSTHIIKLPIRAMNSLSLDLHNSVENEWLCLQILQAFGLPVAQADMHDFGNQRVLVVKRFDRKLS
GDGSWYVRIPQEDFCQAHGLPSSRKYEVDKGVGIQACMDLLQASSQAYGDRKTFLSAHFLYWLMAAPDAHAKNFSLYLEQ
QGRFRMTPLYDVLSLHPVIEQGKGQIFDRKVTLAMGLERRAHRYGWSTMQRQHWLDTAKLCGAEHIMQTIMDETLHDLPQ
VLERLESQLPQDFPQDVAQPIFNGMRKAALRLQS

Nucleotide

• Length: 1305 bp

>T240803 NZ_LT795502:1345381-1345779 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9102.63 Da
• Isoelectric Point: 8.0097

>AT240803 WP_244772718.1 NZ_CP094929:215927-216172 [Sphaerochaeta associata]
MQYPIQTPVQLGSYLRTRRKALGLTQKEAALRIGLLPKTISALENDPLHCSIESLLRLLSALNLEFLLQGKEDAPQGNMW
E

Nucleotide

• Length: 246 bp

>AT240803 NZ_LT795502:1345154-1345381 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA