Detailed information of TA system TA240802

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii(toxin)
• Location: 198906..200346
• Replicon: chromosome
• Accession: NZ_CP094929
• Organism: Sphaerochaeta associata strain GLS2T

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: -
• Locus tag: MUG09_RS00905
• Protein ID: WP_244772703.1
• Coordinates: 199513..200346 (+)
• Length: 278 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: -
• Locus tag: MUG09_RS00900
• Protein ID: WP_244772702.1
• Coordinates: 198906..199520 (+)
• Length: 205 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUG09_RS00880 (MUG09_00880)	194339..195226	+	888	WP_244772698.1	ROK family protein	-
MUG09_RS00885 (MUG09_00885)	195229..195963	+	735	WP_244772699.1	GntR family transcriptional regulator	-
MUG09_RS00890 (MUG09_00890)	195977..197695	+	1719	WP_244772700.1	class I mannose-6-phosphate isomerase	-
MUG09_RS00895 (MUG09_00895)	197809..198765	+	957	WP_244772701.1	D-2-hydroxyacid dehydrogenase	-
MUG09_RS00900 (MUG09_00900)	198906..199520	+	615	WP_244772702.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
MUG09_RS00905 (MUG09_00905)	199513..200346	+	834	WP_244772703.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
MUG09_RS00910 (MUG09_00910)	200400..200684	+	285	WP_244772704.1	NAD(P)-dependent oxidoreductase	-
MUG09_RS00915 (MUG09_00915)	200838..201433	+	596	Protein_181	type III PLP-dependent enzyme	-
MUG09_RS00920 (MUG09_00920)	201506..201847	+	342	WP_244775347.1	hypothetical protein	-
MUG09_RS00925 (MUG09_00925)	202100..202984	+	885	WP_244772705.1	2-hydroxy-3-oxopropionate reductase	-
MUG09_RS00930 (MUG09_00930)	202987..203892	+	906	WP_244772706.1	dihydrodipicolinate synthase family protein	-
MUG09_RS00935 (MUG09_00935)	204098..204889	-	792	WP_244772707.1	IclR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-263)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 278 a.a.
• Molecular weight: 31836.75 Da
• Isoelectric Point: 5.8302

>T240802 WP_244772703.1 NZ_CP094929:199513-200346 [Sphaerochaeta associata]
MNKAGLTALCHTISKDTGLTFNSVMLYYFLENILRKLVQGKYGETLVFKGGFLLSNVVGIESRSTMDIDILVRNMQISEE
NVLAMLTESLKENEGDEIQYEIMGISPIKEQDQYGGYRASILCRFENIRQVIPLDIATGDVITPNPIQYSFSSVFGDDEI
PIKAYPIETMLAEKLQTIYARGFLNSRNKDYYDLHILYKLKSKAIDMPTLVRACEQTFQYRKTEFDLVKIQELLERLKVD
DSFQKRWNAYAKKNNYVHGLSFEAVILDAIRLINKMS

Nucleotide

• Length: 834 bp

>T240802 NZ_LT795502:1048647-1048982 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAAAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 205 a.a.
• Molecular weight: 24053.73 Da
• Isoelectric Point: 9.2517

>AT240802 WP_244772702.1 NZ_CP094929:198906-199520 [Sphaerochaeta associata]
MQQKKRYMDYKKHIEQYLENSGGIITASYCRSKKIPTIYLSRLVREGILQRAAEGLYISEAGMYDAYYYFQYRFKKAVFS
YETALHLLGATDKIPQDMDVTVYYSYKFNKAPLGVNIHYVNKKIHNLGVVETRTMFNNPVRVYSYERTLCDFIAHEDAMD
REVYIKLVRSYAHYAKRDIHTLYEIATSMGLDAKVKTLMELVYE

Nucleotide

• Length: 615 bp

>AT240802 NZ_LT795502:1048399-1048647 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGATAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA