Detailed information of TA system TA240795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2081945..2082474
• Replicon: chromosome
• Accession: NZ_CP094928
• Organism: Staphylococcus aureus strain 8

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MUO44_RS10205
• Protein ID: WP_000621175.1
• Coordinates: 2081945..2082307 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: MUO44_RS10210
• Protein ID: WP_000948331.1
• Coordinates: 2082304..2082474 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO44_RS10185 (MUO44_10185)	2078923..2079693	-	771	WP_001041108.1	RNA polymerase sigma factor SigB	-
MUO44_RS10190 (MUO44_10190)	2079668..2080147	-	480	WP_001190830.1	anti-sigma B factor RsbW	-
MUO44_RS10195 (MUO44_10195)	2080149..2080475	-	327	WP_001052491.1	anti-sigma factor antagonist	-
MUO44_RS10200 (MUO44_10200)	2080594..2081595	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
MUO44_RS10205 (MUO44_10205)	2081945..2082307	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MUO44_RS10210 (MUO44_10210)	2082304..2082474	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MUO44_RS10215 (MUO44_10215)	2082559..2083707	-	1149	WP_001281154.1	alanine racemase	-
MUO44_RS10220 (MUO44_10220)	2083773..2084132	-	360	WP_000581197.1	holo-ACP synthase	-
MUO44_RS10225 (MUO44_10225)	2084136..2084627	-	492	WP_001205912.1	PH domain-containing protein	-
MUO44_RS10230 (MUO44_10230)	2084614..2086197	-	1584	WP_001294626.1	PH domain-containing protein	-
MUO44_RS10235 (MUO44_10235)	2086190..2086669	-	480	WP_001287078.1	hypothetical protein	-
MUO44_RS10240 (MUO44_10240)	2086878..2087438	-	561	WP_001092409.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T240795 WP_000621175.1 NZ_CP094928:c2082307-2081945 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T240795 NZ_LT717701:1515490-1515963 [Mycobacterium terramassiliense]
ATGGCGAAACTATCCGGATCCATCGACGTACCGCTGCCTCCCGAGGTGGCCTGGAAGCACGCCTCCGACCTGTCGCGGTA
CAAGGACTGGCTGACCATCCATCGGGTGTGGCGCAGCACGCTGCCCGACGACATCGACAAGGGGACGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGTACAACCGGATCAAGTGGACGGTCGTGCGCTACAAGCCGCCGGAAGGCATGACGCTCAAC
GGGGATGGCGTCGGCGGGGTCAAGGTCAAGCTGCTGGCCAAGGTTCAACCCGCGGACGAGGGCTCCGTCGTCAGCTTCGA
CGTGCACCTCGGTGGCCCGGCGCTGTTCGGGCCGATCGGCATGATCGTCGCCGCCGCGTTGCGCAGCGACATCAACCAGT
CGCTGCGGAACTTCGTCCGGGTGTTCACCGCCCCCGATCCGCACACGAACGGGGACGGCGGCGTCCGTCGCTGA

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT240795 WP_000948331.1 NZ_CP094928:c2082474-2082304 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT240795 NZ_LT717701:1515297-1515485 [Mycobacterium terramassiliense]
ATGGGATTCCTGGACAAGGCCAAGGACCTGTTGGCGCAAAACGCCGACAAGGTCGAGACCGCGATAGACAAGGCCGGCGA
ATTCGTCGACGGCAGGACGCAGGGAAAGTACTCGGACACCATCCACAAGGTGGCCGAAGAGGCCAAGAAAGCGGCCGATT
CCGCCGTCCAGAACGACCCGCAGAACTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1