Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1909257..1910033 Replicon chromosome
Accession NZ_CP094928
Organism Staphylococcus aureus strain 8

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUO44_RS09180 Protein ID WP_000031108.1
Coordinates 1909257..1909409 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag MUO44_RS09185 Protein ID WP_001251224.1
Coordinates 1909434..1910033 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO44_RS09165 (MUO44_09165) 1905393..1906214 + 822 WP_000669376.1 RluA family pseudouridine synthase -
MUO44_RS09170 (MUO44_09170) 1906675..1908060 - 1386 WP_000116229.1 class II fumarate hydratase -
MUO44_RS09175 (MUO44_09175) 1908256..1908651 - 396 WP_000901023.1 hypothetical protein -
MUO44_RS09180 (MUO44_09180) 1909257..1909409 - 153 WP_000031108.1 SAS053 family protein Toxin
MUO44_RS09185 (MUO44_09185) 1909434..1910033 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
MUO44_RS09190 (MUO44_09190) 1910192..1910662 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUO44_RS09195 (MUO44_09195) 1910667..1911794 - 1128 WP_277446050.1 tRNA epoxyqueuosine(34) reductase QueG -
MUO44_RS09200 (MUO44_09200) 1911945..1912667 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUO44_RS09205 (MUO44_09205) 1912660..1914117 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240794 WP_000031108.1 NZ_CP094928:c1909409-1909257 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT240794 WP_001251224.1 NZ_CP094928:c1910033-1909434 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References