Detailed information of TA system TA240791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 827329..827806
• Replicon: chromosome
• Accession: NZ_CP094928
• Organism: Staphylococcus aureus strain 8

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUO44_RS03910
• Protein ID: WP_000052076.1
• Coordinates: 827329..827517 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUO44_RS03915
• Protein ID: WP_001059690.1
• Coordinates: 827546..827806 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO44_RS03880 (MUO44_03880)	823319..823840	+	522	WP_000824464.1	hypothetical protein	-
MUO44_RS03885 (MUO44_03885)	824181..824867	+	687	WP_001793574.1	thermonuclease family protein	-
MUO44_RS03890 (MUO44_03890)	825224..825424	+	201	WP_001059082.1	cold-shock protein	-
MUO44_RS03895 (MUO44_03895)	825920..826138	-	219	WP_000005886.1	hypothetical protein	-
MUO44_RS03900 (MUO44_03900)	826200..826484	-	285	WP_001004401.1	hypothetical protein	-
MUO44_RS03905 (MUO44_03905)	826572..827141	-	570	WP_001106654.1	lipoprotein N-acylation protein LnsA	-
MUO44_RS03910 (MUO44_03910)	827329..827517	-	189	WP_000052076.1	hypothetical protein	Toxin
MUO44_RS03915 (MUO44_03915)	827546..827806	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUO44_RS03920 (MUO44_03920)	828146..828349	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUO44_RS03925 (MUO44_03925)	828346..828582	-	237	WP_000368687.1	hypothetical protein	-
MUO44_RS03930 (MUO44_03930)	828806..829387	+	582	WP_001140696.1	histidine phosphatase family protein	-
MUO44_RS03935 (MUO44_03935)	829460..830077	-	618	WP_000255544.1	LysE/ArgO family amino acid transporter	-
MUO44_RS03940 (MUO44_03940)	830232..830726	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MUO44_RS03945 (MUO44_03945)	831125..831547	-	423	WP_000974464.1	organic hydroperoxide resistance protein	-
MUO44_RS03950 (MUO44_03950)	831695..832411	+	717	WP_000150012.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (2-103)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-51)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240791 WP_000052076.1 NZ_CP094928:c827517-827329 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240791 NZ_LT706985:1468571-1468897 [Propionimicrobium sp. Marseille-P3275]
ATGCGAGGTGAGATCTGGACGGTCTGTGCATCTGGCTATGCCTCTAAGCCTCGTCCTGCGGTGATTGTGCAAGCGGATAG
CGTTGTAGGTTTCGACTCCACCATTGTTTGTCTGTTCACCACCGACGACAGCCTGAAGGGTGCTACGCGAGTAAGCGTGA
AGGCGACTGGCGGCAATGGGCTAACAAAAGATTGCATAGTTATGGCCGAAAAGCCGGTTGCGATAAACAAGTCCAGGCTT
GGCGAAAAACTTGGTGCCCTGGAAGCTGAAACACTGAGCAAAGTGGGGTCAGCGCTGAGGCAAGTTTTTGGCTTCGGCGT
TGGCTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240791 WP_001059690.1 NZ_CP094928:c827806-827546 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240791 NZ_LT706985:1468345-1468581 [Propionimicrobium sp. Marseille-P3275]
ATGGTTCAGCTCGCTACTCGTGTTGACGATGAGGACGGAAAGACGTTCAAGGATTTGACCAAGCGGTTGGGCACTACGCC
CGCTGACGCAATAAGAATGTTCGTTATGGCTTTTAACGCCAACCGTGGTTTCCCGTACGAAGTCAGGTTGAGTGATGCGC
AGCCCTTCGAAAGTGAAAAAGAGGCCGTCAATTTTATAGATGATCTTGCAACGGAAACGATTTCCGATGCGAGGTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56