Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 2853871..2854668 | Replicon | chromosome |
| Accession | NZ_CP094927 | ||
| Organism | Staphylococcus aureus strain 13 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | MUO46_RS14300 | Protein ID | WP_000525004.1 |
| Coordinates | 2853871..2854332 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUO46_RS14305 | Protein ID | WP_001260485.1 |
| Coordinates | 2854345..2854668 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO46_RS14270 (MUO46_14230) | 2849724..2850527 | + | 804 | WP_000928413.1 | TerC family protein | - |
| MUO46_RS14275 (MUO46_14235) | 2850816..2852021 | - | 1206 | WP_000264741.1 | site-specific integrase | - |
| MUO46_RS14280 (MUO46_14240) | 2852147..2852761 | + | 615 | WP_000191466.1 | hypothetical protein | - |
| MUO46_RS14285 (MUO46_14245) | 2852758..2852904 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| MUO46_RS14290 (MUO46_14250) | 2852995..2853390 | - | 396 | WP_000449655.1 | hypothetical protein | - |
| MUO46_RS14295 (MUO46_14255) | 2853419..2853853 | - | 435 | WP_000755719.1 | hypothetical protein | - |
| MUO46_RS14300 (MUO46_14260) | 2853871..2854332 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| MUO46_RS14305 (MUO46_14265) | 2854345..2854668 | - | 324 | WP_001260485.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUO46_RS14310 (MUO46_14270) | 2854832..2855080 | + | 249 | WP_000272860.1 | helix-turn-helix transcriptional regulator | - |
| MUO46_RS14315 (MUO46_14275) | 2855096..2855341 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MUO46_RS14320 (MUO46_14280) | 2855310..2855675 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| MUO46_RS14325 (MUO46_14285) | 2855730..2855945 | + | 216 | WP_001036302.1 | hypothetical protein | - |
| MUO46_RS14330 (MUO46_14290) | 2855970..2856233 | + | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| MUO46_RS14335 (MUO46_14295) | 2856246..2856407 | + | 162 | WP_001285963.1 | DUF1270 family protein | - |
| MUO46_RS14340 (MUO46_14300) | 2856486..2856809 | + | 324 | WP_000174994.1 | hypothetical protein | - |
| MUO46_RS14345 (MUO46_14305) | 2856824..2857186 | + | 363 | WP_150868153.1 | hypothetical protein | - |
| MUO46_RS14350 (MUO46_14310) | 2857183..2858349 | + | 1167 | WP_277445891.1 | DUF2800 domain-containing protein | - |
| MUO46_RS14355 (MUO46_14315) | 2858376..2858930 | + | 555 | WP_000647288.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2850816..2871938 | 21122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T240787 WP_000525004.1 NZ_CP094927:c2854332-2853871 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T240787 NZ_LT706985:c586372-586196 [Propionimicrobium sp. Marseille-P3275]
ATGCGGCAAAACCGTGACGAGCTGCGCACCCGCTATCGCGACCATGCATTGCAGGGAAACCGGAAAGGATACCGAGAAAT
TCACCTTGAAGGTGATTGGCTGCTGATCTACCGTGTGGAACATAGCGAGTTGCTTCTTGTGCTCACTCGAACTGGCTCTC
ACGATGACCTGTTCTAG
ATGCGGCAAAACCGTGACGAGCTGCGCACCCGCTATCGCGACCATGCATTGCAGGGAAACCGGAAAGGATACCGAGAAAT
TCACCTTGAAGGTGATTGGCTGCTGATCTACCGTGTGGAACATAGCGAGTTGCTTCTTGTGCTCACTCGAACTGGCTCTC
ACGATGACCTGTTCTAG
Antitoxin
Download Length: 108 a.a. Molecular weight: 12439.16 Da Isoelectric Point: 9.3811
>AT240787 WP_001260485.1 NZ_CP094927:c2854668-2854345 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT240787 NZ_LT706985:c586720-586466 [Propionimicrobium sp. Marseille-P3275]
ATGGCTAATGTTTCTTTCCGGACGGATGATGAGACGAAAGCTCAGGCCGCGGAGTTGTTCCGTGATCTCGGGTTAGATAT
GAGCACTGCTATCAATATGTTTTTGAGGCAGTCGATTGTTAGCAATGGTATCCCGTTCACGCCACACCGCGAGAGTCCAA
CTAGCGCCTTGGCGAGAGCTGAAGTTGAGTCTCGCTCTGGTGCTTCGTTTCGAAATGGCGCTGAGCTGATGGCAGATCTC
AATGAAGCTGACTAG
ATGGCTAATGTTTCTTTCCGGACGGATGATGAGACGAAAGCTCAGGCCGCGGAGTTGTTCCGTGATCTCGGGTTAGATAT
GAGCACTGCTATCAATATGTTTTTGAGGCAGTCGATTGTTAGCAATGGTATCCCGTTCACGCCACACCGCGAGAGTCCAA
CTAGCGCCTTGGCGAGAGCTGAAGTTGAGTCTCGCTCTGGTGCTTCGTTTCGAAATGGCGCTGAGCTGATGGCAGATCTC
AATGAAGCTGACTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|