Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2718572..2719049 Replicon chromosome
Accession NZ_CP094927
Organism Staphylococcus aureus strain 13

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUO46_RS13620 Protein ID WP_000052076.1
Coordinates 2718572..2718760 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUO46_RS13625 Protein ID WP_001059690.1
Coordinates 2718789..2719049 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2715319..2716638 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240786 WP_000052076.1 NZ_CP094927:c2718760-2718572 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240786 NZ_LT706985:c576670-576323 [Propionimicrobium sp. Marseille-P3275]
ATGCGGCGCGGTGAAATCCGACTGGTAAATCTTGACCCGGTTGTCGGAAGTGAATCAAACAAGCTGCGTCCCTGTGTCAT
CGTGAGTAATAACAATGCAAATGATACGGCTGAACTATTGGGGCGTGGGGTAGTGACCGTCGTTCCGCTGACGAGCAATA
CTATGCGTGTTTACCCGTTTCAAACTTTGCTAGACTCAGCCGATACTGGGCTGGGGGAGGATTCTAAAGCGCAGGCAGAA
CAAGTACGTTCGGTTGATGTTCGCCGTATCGGCAAGAAAATCGGCCAGCTATCCATGAGACAACAATTCGCCCTTGACGA
GGCCTTACGTTTACACCTGCAGTTGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240786 WP_001059690.1 NZ_CP094927:c2719049-2718789 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240786 NZ_LT706985:c576896-576657 [Propionimicrobium sp. Marseille-P3275]
ATGAAGCTAAGTGTTAGTCTGTCTAATAGTGACCTAGAACTGCTTGATCGTATCGTTAGTGAGGCAGGTCTAGCGTCTAG
GTCTGCCGGCGTTCAACTGGCTTTGAAGAGTTTGGTGGATCCAAATCTTCGCGACGCTTATGCGAGTGCATGGCGTGAAT
GGGCTAGCGACTCTGACAACCTGGCTTGGGACACTGCCGTCAACGACGGGTTTGAGGAACTTGGCCATGCGGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References