Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2718572..2719049 | Replicon | chromosome |
| Accession | NZ_CP094927 | ||
| Organism | Staphylococcus aureus strain 13 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MUO46_RS13620 | Protein ID | WP_000052076.1 |
| Coordinates | 2718572..2718760 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MUO46_RS13625 | Protein ID | WP_001059690.1 |
| Coordinates | 2718789..2719049 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO46_RS13585 (MUO46_13545) | 2713903..2714589 | + | 687 | WP_001548082.1 | thermonuclease family protein | - |
| MUO46_RS13590 (MUO46_13550) | 2714947..2715147 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MUO46_RS13595 (MUO46_13555) | 2715238..2715300 | - | 63 | Protein_2637 | hypothetical protein | - |
| MUO46_RS13600 (MUO46_13560) | 2715319..2716638 | - | 1320 | WP_001808146.1 | ISL3-like element IS1181 family transposase | - |
| MUO46_RS13605 (MUO46_13565) | 2717163..2717381 | - | 219 | WP_000005884.1 | hypothetical protein | - |
| MUO46_RS13610 (MUO46_13570) | 2717443..2717727 | - | 285 | WP_001004394.1 | hypothetical protein | - |
| MUO46_RS13615 (MUO46_13575) | 2717815..2718384 | - | 570 | WP_001106653.1 | lipoprotein N-acylation protein LnsA | - |
| MUO46_RS13620 (MUO46_13580) | 2718572..2718760 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MUO46_RS13625 (MUO46_13585) | 2718789..2719049 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MUO46_RS13630 (MUO46_13590) | 2719390..2719593 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MUO46_RS13635 (MUO46_13595) | 2719590..2719826 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| MUO46_RS13640 (MUO46_13600) | 2720051..2720632 | + | 582 | WP_001140697.1 | histidine phosphatase family protein | - |
| MUO46_RS13645 (MUO46_13605) | 2720705..2721322 | - | 618 | WP_000255553.1 | LysE/ArgO family amino acid transporter | - |
| MUO46_RS13650 (MUO46_13610) | 2721477..2721971 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| MUO46_RS13655 (MUO46_13615) | 2722370..2722792 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| MUO46_RS13660 (MUO46_13620) | 2722940..2723656 | + | 717 | WP_000150013.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2715319..2716638 | 1319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T240786 WP_000052076.1 NZ_CP094927:c2718760-2718572 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T240786 NZ_LT706985:c576670-576323 [Propionimicrobium sp. Marseille-P3275]
ATGCGGCGCGGTGAAATCCGACTGGTAAATCTTGACCCGGTTGTCGGAAGTGAATCAAACAAGCTGCGTCCCTGTGTCAT
CGTGAGTAATAACAATGCAAATGATACGGCTGAACTATTGGGGCGTGGGGTAGTGACCGTCGTTCCGCTGACGAGCAATA
CTATGCGTGTTTACCCGTTTCAAACTTTGCTAGACTCAGCCGATACTGGGCTGGGGGAGGATTCTAAAGCGCAGGCAGAA
CAAGTACGTTCGGTTGATGTTCGCCGTATCGGCAAGAAAATCGGCCAGCTATCCATGAGACAACAATTCGCCCTTGACGA
GGCCTTACGTTTACACCTGCAGTTGTAA
ATGCGGCGCGGTGAAATCCGACTGGTAAATCTTGACCCGGTTGTCGGAAGTGAATCAAACAAGCTGCGTCCCTGTGTCAT
CGTGAGTAATAACAATGCAAATGATACGGCTGAACTATTGGGGCGTGGGGTAGTGACCGTCGTTCCGCTGACGAGCAATA
CTATGCGTGTTTACCCGTTTCAAACTTTGCTAGACTCAGCCGATACTGGGCTGGGGGAGGATTCTAAAGCGCAGGCAGAA
CAAGTACGTTCGGTTGATGTTCGCCGTATCGGCAAGAAAATCGGCCAGCTATCCATGAGACAACAATTCGCCCTTGACGA
GGCCTTACGTTTACACCTGCAGTTGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT240786 WP_001059690.1 NZ_CP094927:c2719049-2718789 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT240786 NZ_LT706985:c576896-576657 [Propionimicrobium sp. Marseille-P3275]
ATGAAGCTAAGTGTTAGTCTGTCTAATAGTGACCTAGAACTGCTTGATCGTATCGTTAGTGAGGCAGGTCTAGCGTCTAG
GTCTGCCGGCGTTCAACTGGCTTTGAAGAGTTTGGTGGATCCAAATCTTCGCGACGCTTATGCGAGTGCATGGCGTGAAT
GGGCTAGCGACTCTGACAACCTGGCTTGGGACACTGCCGTCAACGACGGGTTTGAGGAACTTGGCCATGCGGCGCGGTGA
ATGAAGCTAAGTGTTAGTCTGTCTAATAGTGACCTAGAACTGCTTGATCGTATCGTTAGTGAGGCAGGTCTAGCGTCTAG
GTCTGCCGGCGTTCAACTGGCTTTGAAGAGTTTGGTGGATCCAAATCTTCGCGACGCTTATGCGAGTGCATGGCGTGAAT
GGGCTAGCGACTCTGACAACCTGGCTTGGGACACTGCCGTCAACGACGGGTTTGAGGAACTTGGCCATGCGGCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |