Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1528419..1529210 | Replicon | chromosome |
| Accession | NZ_CP094927 | ||
| Organism | Staphylococcus aureus strain 13 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A380E6V7 |
| Locus tag | MUO46_RS07935 | Protein ID | WP_000525007.1 |
| Coordinates | 1528746..1529210 (+) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | MUO46_RS07930 | Protein ID | WP_000333630.1 |
| Coordinates | 1528419..1528733 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO46_RS07875 (MUO46_07845) | 1523802..1524353 | - | 552 | WP_000704705.1 | single-stranded DNA-binding protein | - |
| MUO46_RS07880 (MUO46_07850) | 1524382..1525170 | - | 789 | WP_000134097.1 | ATP-binding protein | - |
| MUO46_RS07885 (MUO46_07855) | 1525163..1525384 | - | 222 | WP_000815401.1 | DUF2483 family protein | - |
| MUO46_RS07890 (MUO46_07860) | 1525394..1525654 | - | 261 | WP_107386909.1 | DUF1108 family protein | - |
| MUO46_RS07895 (MUO46_07865) | 1525746..1525907 | - | 162 | WP_000066021.1 | DUF1270 family protein | - |
| MUO46_RS07900 (MUO46_07870) | 1525919..1526182 | - | 264 | WP_001124198.1 | helix-turn-helix domain-containing protein | - |
| MUO46_RS07905 (MUO46_07875) | 1526332..1526430 | - | 99 | Protein_1523 | hypothetical protein | - |
| MUO46_RS07910 (MUO46_07880) | 1526446..1527195 | - | 750 | WP_001148586.1 | phage antirepressor KilAC domain-containing protein | - |
| MUO46_RS07915 (MUO46_07885) | 1527255..1527737 | + | 483 | WP_000394410.1 | hypothetical protein | - |
| MUO46_RS07920 (MUO46_07890) | 1527838..1528017 | - | 180 | WP_000438352.1 | hypothetical protein | - |
| MUO46_RS07925 (MUO46_07895) | 1528031..1528267 | - | 237 | WP_001121116.1 | helix-turn-helix transcriptional regulator | - |
| MUO46_RS07930 (MUO46_07900) | 1528419..1528733 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUO46_RS07935 (MUO46_07905) | 1528746..1529210 | + | 465 | WP_000525007.1 | hypothetical protein | Toxin |
| MUO46_RS07940 (MUO46_07910) | 1529242..1530174 | + | 933 | WP_000392183.1 | hypothetical protein | - |
| MUO46_RS07945 (MUO46_07915) | 1530154..1530333 | - | 180 | WP_000337827.1 | hypothetical protein | - |
| MUO46_RS07950 (MUO46_07920) | 1530444..1531649 | + | 1206 | WP_000264186.1 | tyrosine-type recombinase/integrase | - |
| MUO46_RS07955 (MUO46_07925) | 1531743..1531838 | - | 96 | Protein_1533 | QueT transporter family protein | - |
| MUO46_RS07960 (MUO46_07930) | 1531849..1532541 | - | 693 | WP_000286877.1 | 6-carboxyhexanoate--CoA ligase | - |
| MUO46_RS07965 (MUO46_07935) | 1532552..1533667 | - | 1116 | WP_024273594.1 | pyridoxal phosphate-dependent aminotransferase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | sbi / hlgA / hlgC / hlgB | 1474511..1541981 | 67470 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 18100.42 Da Isoelectric Point: 4.7904
>T240782 WP_000525007.1 NZ_CP094927:1528746-1529210 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID
Download Length: 465 bp
>T240782 NZ_LT703507:25791-26048 [Mycobacterium intracellulare subsp. chimaera]
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCGCGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGATGATCACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA
GTGAGAAGCATCAACTTCGATCCCGCCGCGTGGGAGGACTTTCTATTTTGGCTGGCTTCCGACCGCAAAACAGCACGGCG
CATCACCAGACTCATCGCAGAAATCCAGCGCAACCCGTTTGCTGGGATTGGAAAACCAGAACCGCTCAAGGGTGAACTAT
CCGGGTACTGGTCGCGGCGCATCGACGACGAACACCGGATCGTCTACCGCGCAGATGATCACGAAATCAAGATCCTCAAA
GCCCGATACCACTACTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT240782 WP_000333630.1 NZ_CP094927:1528419-1528733 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT240782 NZ_LT703507:25510-25794 [Mycobacterium intracellulare subsp. chimaera]
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
AATTACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA
ATGGCTATCAGTGCAAGTGAGGCCCGGCAGCGCCTCTTTCCGCTGCTTGAACAAGTCAACACCGACCACGAGCCTGTGCG
AATTACGTCCAAGGCCGGAGATGCAGTGCTCATGTCGGCCGCTGACTACGATTCGTGGCAAGAAACGGTCTACCTCCTGC
GTTCCCCCGAGAATGCCCGCCGACTCATGGAGGCCGTCGCCCGAGACAACGCCACCCGGCCCACCCCCGGCAGCTACACC
AAGTCGATCGACGAACTCGAGGAGATGGCCGGCGGCCAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A380E6V7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |