240780

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1161076..1161590 Replicon chromosome
Accession NZ_CP094927
Organism Staphylococcus aureus strain 13

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUO46_RS05885 Protein ID WP_000581792.1
Coordinates 1161076..1161285 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MUO46_RS05890 Protein ID WP_000138932.1
Coordinates 1161297..1161590 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO46_RS05865 (MUO46_05830) 1156584..1157942 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUO46_RS05870 (MUO46_05835) 1157957..1159027 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUO46_RS05875 (MUO46_05840) 1159345..1160547 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUO46_RS05880 (MUO46_05845) 1160811..1160948 - 138 WP_000828354.1 Lmo0850 family protein -
MUO46_RS05885 (MUO46_05850) 1161076..1161285 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUO46_RS05890 (MUO46_05855) 1161297..1161590 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUO46_RS05895 (MUO46_05860) 1161756..1163240 + 1485 WP_000571549.1 cardiolipin synthase -
MUO46_RS05900 (MUO46_05865) 1163268..1163915 + 648 WP_001187630.1 HD domain-containing protein -
MUO46_RS05905 (MUO46_05870) 1164520..1165392 - 873 WP_277445901.1 membrane protein insertase YidC -
MUO46_RS05910 (MUO46_05875) 1165478..1166119 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240780 WP_000581792.1 NZ_CP094927:c1161285-1161076 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240780 NZ_CP094927:c1161285-1161076 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT240780 WP_000138932.1 NZ_CP094927:c1161590-1161297 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240780 NZ_CP094927:c1161590-1161297 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References