Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1141322..1141851 Replicon chromosome
Accession NZ_CP094927
Organism Staphylococcus aureus strain 13

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag MUO46_RS05795 Protein ID WP_000621175.1
Coordinates 1141322..1141684 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag MUO46_RS05800 Protein ID WP_000948331.1
Coordinates 1141681..1141851 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO46_RS05775 (MUO46_05740) 1138300..1139070 - 771 WP_001041102.1 RNA polymerase sigma factor SigB -
MUO46_RS05780 (MUO46_05745) 1139045..1139524 - 480 WP_001190829.1 anti-sigma B factor RsbW -
MUO46_RS05785 (MUO46_05750) 1139526..1139852 - 327 WP_024273281.1 anti-sigma factor antagonist -
MUO46_RS05790 (MUO46_05755) 1139971..1140972 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
MUO46_RS05795 (MUO46_05760) 1141322..1141684 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUO46_RS05800 (MUO46_05765) 1141681..1141851 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUO46_RS05805 (MUO46_05770) 1141936..1143084 - 1149 WP_001281154.1 alanine racemase -
MUO46_RS05810 (MUO46_05775) 1143150..1143509 - 360 WP_000581197.1 holo-ACP synthase -
MUO46_RS05815 (MUO46_05780) 1143513..1144004 - 492 WP_001205912.1 PH domain-containing protein -
MUO46_RS05820 (MUO46_05785) 1143991..1145574 - 1584 WP_024273279.1 PH domain-containing protein -
MUO46_RS05825 (MUO46_05790) 1145567..1146046 - 480 WP_001287079.1 hypothetical protein -
MUO46_RS05830 (MUO46_05795) 1146255..1146815 - 561 WP_001092409.1 K(+)-transporting ATPase subunit C -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T240779 WP_000621175.1 NZ_CP094927:c1141684-1141322 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T240779 NZ_LT703505:2846203-2846781 [Mycobacterium intracellulare subsp. chimaera]
ATGCAGCGACTTGACCTGGTGGTCGGGCCGAACGGTGCCGGCAAGTCGACCTTCATCGCGTTCACCCTGGCGCCGCTGTT
GCCCGGCAGCCCGGTCGTCAACGCCGACGAAATCGCAAGGCAGCGCTGGCCGGAGGAGTCGGCGGGGCGCGCCTACGACG
CCGCGCAAATCGCCGCCGACACGCGCGCGAAGTTGATCGACCTGGGTCGGTCGTTCATCGCGGAGACCGTGTTTTCCCAC
CCGTCGAAGCTGGACCTCATCCGCACCGCCCACCGAGCGGGCTTCACCGTCGTCCTGCACGCGATGCTCATCCCGGAAGA
CCTTGCCGTCGAACGTGTCCGGCACCGCGTGCGGGCCGGCGGCCACGACGTACCGGAAACCAAGGTTCGCGAGCGCCATC
GTCGCTTGTGGACACCGGTCACCGACGCCATCGCGCTGTCCGACGTCGCCACCGTCTACGACAACAGCCGGCTGCGCGGG
CCGCGCATCGTCGCCCGCCTCACCGGCGGCATGACAATCGGTTCACCGGACTGGCCCGCGTGGACGCCAGGGACCTTGCG
GTCACGCTGGGCGGACTAA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT240779 WP_000948331.1 NZ_CP094927:c1141851-1141681 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT240779 NZ_LT703505:2845789-2846178 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCGACGCTCCCGATCGTGTGACCCGCGTGGCGTCCGACCTGATGGACAGCGCGGCCTCCGAAGGCGCCCGCCAGAG
CCGTTCGGCCAAGCAGCAACTCGACCACTGGGCGCGTGTCGGGCGCGCGGTGTCCAGCCAGCACACCGCCTCGCGTCGGC
GGGTCGAGGCCGCGATGGCCGGCCAGCTGGCGACCGGCGAACTCACCGTCGAGGAAGGCGTGGTGTTCAACGCCGAGATC
TCCGCGGCTATTGAAGAAAGCCTGGTGCACGCCAACTACGGGGCGACGCTGGCCGGGCATGGCGTCACCACGGTCGCCCT
CAACGAGGACGGCGACATCGTCGAGCACCGGCCCGATGGCGCCGCCGTGGTGCTGGCGCGCGGGCGCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References