Detailed information of TA system TA240778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 957193..957969
• Replicon: chromosome
• Accession: NZ_CP094927
• Organism: Staphylococcus aureus strain 13

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MUO46_RS04725
• Protein ID: WP_000031108.1
• Coordinates: 957193..957345 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: MUO46_RS04730
• Protein ID: WP_001251224.1
• Coordinates: 957370..957969 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO46_RS04710 (MUO46_04675)	953400..954221	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
MUO46_RS04715 (MUO46_04680)	954673..956058	-	1386	WP_000116229.1	class II fumarate hydratase	-
MUO46_RS04720 (MUO46_04685)	956254..956649	-	396	WP_000901023.1	hypothetical protein	-
MUO46_RS04725 (MUO46_04690)	957193..957345	-	153	WP_000031108.1	SAS053 family protein	Toxin
MUO46_RS04730 (MUO46_04695)	957370..957969	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
MUO46_RS04735 (MUO46_04700)	958128..958598	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUO46_RS04740 (MUO46_04705)	958603..959730	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUO46_RS04745 (MUO46_04710)	959882..960604	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
MUO46_RS04750 (MUO46_04715)	960597..962054	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T240778 WP_000031108.1 NZ_CP094927:c957345-957193 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T240778 NZ_LT703505:2514963-2515370 [Mycobacterium intracellulare subsp. chimaera]
ATGAGCAACCCGCAGGTGGCCGGAGTGCTCGACACTTCGGTGTTCATCGCGACCGAAAGTGGTCGGCCTCTCGACGCGGC
GCTGATCCCTGATCAAGTTGGCACTACGGTTGTTACCCTCGCGGAACTGCACGTTGGTGTGTTGGCCGCGTCGACTTCCG
ATATTAGAGCGCAGCGCCTCGCGACATTGGAATCCATTGCGGATATCGAAGCGCTGCCGGTCGATGACGATGCGGCCCGG
ATGTGGGCCCGGCTGCGGATCCATCTCGCCGAGACCGGTCAACGCGTCCGGATCAACGATCTGTGGATCGCGGCCATCGC
GGCGTCCCGAGGGCTACCTGTTGTCACGCAGGACGATGACTTTGCCGTCTTGGATGGTGCGGCCAATTTGACCGTTATCC
GCGTCTGA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT240778 WP_001251224.1 NZ_CP094927:c957969-957370 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT240778 NZ_LT703505:2514706-2514966 [Mycobacterium intracellulare subsp. chimaera]
ATGTCTGAAGTGGCATCTCGTGAGCTGCGCAACGATACGGCTGGGGTGCTGCGGCGGGTTCGGGATGGAGAGGACGTCAC
CATCACTGTCAGTGGCCGACCGGTCGCAGTTCTTACCGCAGTTGTCCCTCAGCGCAGGCGTTGGCTGAGCAAGACGGAGT
TGCTGTCGCGCTTGCCCCGCGTTCAAGCGGATCCGGGATTACGCGAGGACCTTCACGCACTCGCCGGCGACACTACCGAG
GAGCTGGGCCCGATCCGATGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4