Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 2838164..2838961 | Replicon | chromosome |
| Accession | NZ_CP094926 | ||
| Organism | Staphylococcus aureus strain 14 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | MUO45_RS14185 | Protein ID | WP_000525004.1 |
| Coordinates | 2838164..2838625 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUO45_RS14190 | Protein ID | WP_001260485.1 |
| Coordinates | 2838638..2838961 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO45_RS14155 (MUO45_14120) | 2834017..2834820 | + | 804 | WP_000928413.1 | TerC family protein | - |
| MUO45_RS14160 (MUO45_14125) | 2835109..2836314 | - | 1206 | WP_000264741.1 | site-specific integrase | - |
| MUO45_RS14165 (MUO45_14130) | 2836440..2837054 | + | 615 | WP_000191466.1 | hypothetical protein | - |
| MUO45_RS14170 (MUO45_14135) | 2837051..2837197 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| MUO45_RS14175 (MUO45_14140) | 2837288..2837683 | - | 396 | WP_000449655.1 | hypothetical protein | - |
| MUO45_RS14180 (MUO45_14145) | 2837712..2838146 | - | 435 | WP_000755719.1 | hypothetical protein | - |
| MUO45_RS14185 (MUO45_14150) | 2838164..2838625 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| MUO45_RS14190 (MUO45_14155) | 2838638..2838961 | - | 324 | WP_001260485.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUO45_RS14195 (MUO45_14160) | 2839125..2839373 | + | 249 | WP_000272860.1 | helix-turn-helix transcriptional regulator | - |
| MUO45_RS14200 (MUO45_14165) | 2839389..2839634 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MUO45_RS14205 (MUO45_14170) | 2839603..2839968 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| MUO45_RS14210 (MUO45_14175) | 2840023..2840238 | + | 216 | WP_001036302.1 | hypothetical protein | - |
| MUO45_RS14215 (MUO45_14180) | 2840263..2840526 | + | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| MUO45_RS14220 (MUO45_14185) | 2840539..2840700 | + | 162 | WP_001285963.1 | DUF1270 family protein | - |
| MUO45_RS14225 (MUO45_14190) | 2840779..2841102 | + | 324 | WP_000174994.1 | hypothetical protein | - |
| MUO45_RS14230 (MUO45_14195) | 2841117..2841479 | + | 363 | WP_150868153.1 | hypothetical protein | - |
| MUO45_RS14235 (MUO45_14200) | 2841476..2842642 | + | 1167 | WP_277445891.1 | DUF2800 domain-containing protein | - |
| MUO45_RS14240 (MUO45_14205) | 2842669..2843223 | + | 555 | WP_000647288.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2835109..2856231 | 21122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T240774 WP_000525004.1 NZ_CP094926:c2838625-2838164 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T240774 NZ_LT703505:1501766-1502011 [Mycobacterium intracellulare subsp. chimaera]
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCGGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCCCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA
ATGACGGCAGCTGCGAAGAGGGCGCTCACTCATTTGTTGCCCGAGTCGGTGGCCATTGCTTGCTGGGAGTTCATTCGGGG
TCCGCTCGCGGAGAACCCGCAGCGGGTGGGCAAGCCGCTTCGCGGCCAGTTGGAAGGGCGATACTCGGCGCGCAGGGGCG
AGTTTCGCGTCATTTACCGGATCTTCGACGAACGGGTGGTGGTCCCCGTCATCCACATCGCGCATCGCCGCGACGTTTAC
CGGTGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12439.16 Da Isoelectric Point: 9.3811
>AT240774 WP_001260485.1 NZ_CP094926:c2838961-2838638 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT240774 NZ_LT703505:1501467-1501751 [Mycobacterium intracellulare subsp. chimaera]
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA
ATGTCGACGCTTCCGCTGGCCGAGGTCCGAGCCAACCTTTCCAAGCTGGTCGACGAGGCCGTCCGGACCCATGAGCGCAT
CGAGGTCACCAGGCAAGGTCGCCGCGCGGCGGTGATTCTCAGCGCGGATGACTTCGATTCGATTATGGAAACTCTGGCCA
TCCTCAGCGATCAAGACTTGATGCGCGAAGTCCGAGCGGCAGAGTCAGAGGCAGAGGACGGCGCGCTCTACACACTCGAT
CAGGTGACCGAGGAGATGCGTGCTGTCGGCCGGCTCCCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|