Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2702865..2703342 Replicon chromosome
Accession NZ_CP094926
Organism Staphylococcus aureus strain 14

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUO45_RS13505 Protein ID WP_000052076.1
Coordinates 2702865..2703053 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUO45_RS13510 Protein ID WP_001059690.1
Coordinates 2703082..2703342 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO45_RS13470 (MUO45_13435) 2698196..2698882 + 687 WP_001548082.1 thermonuclease family protein -
MUO45_RS13475 (MUO45_13440) 2699240..2699440 + 201 WP_001059082.1 cold-shock protein -
MUO45_RS13480 (MUO45_13445) 2699531..2699593 - 63 Protein_2614 hypothetical protein -
MUO45_RS13485 (MUO45_13450) 2699612..2700931 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -
MUO45_RS13490 (MUO45_13455) 2701456..2701674 - 219 WP_000005884.1 hypothetical protein -
MUO45_RS13495 (MUO45_13460) 2701736..2702020 - 285 WP_001004394.1 hypothetical protein -
MUO45_RS13500 (MUO45_13465) 2702108..2702677 - 570 WP_001106653.1 lipoprotein N-acylation protein LnsA -
MUO45_RS13505 (MUO45_13470) 2702865..2703053 - 189 WP_000052076.1 hypothetical protein Toxin
MUO45_RS13510 (MUO45_13475) 2703082..2703342 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUO45_RS13515 (MUO45_13480) 2703683..2703886 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUO45_RS13520 (MUO45_13485) 2703883..2704119 - 237 WP_000368687.1 hypothetical protein -
MUO45_RS13525 (MUO45_13490) 2704344..2704925 + 582 WP_001140697.1 histidine phosphatase family protein -
MUO45_RS13530 (MUO45_13495) 2704998..2705615 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
MUO45_RS13535 (MUO45_13500) 2705770..2706264 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MUO45_RS13540 (MUO45_13505) 2706663..2707085 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
MUO45_RS13545 (MUO45_13510) 2707233..2707949 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2699612..2700931 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240773 WP_000052076.1 NZ_CP094926:c2703053-2702865 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240773 NZ_LT703505:1259710-1260171 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACTATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240773 WP_001059690.1 NZ_CP094926:c2703342-2703082 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240773 NZ_LT703505:1259518-1259706 [Mycobacterium intracellulare subsp. chimaera]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCGGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References