Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2702865..2703342 | Replicon | chromosome |
| Accession | NZ_CP094926 | ||
| Organism | Staphylococcus aureus strain 14 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | MUO45_RS13505 | Protein ID | WP_000052076.1 |
| Coordinates | 2702865..2703053 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | MUO45_RS13510 | Protein ID | WP_001059690.1 |
| Coordinates | 2703082..2703342 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO45_RS13470 (MUO45_13435) | 2698196..2698882 | + | 687 | WP_001548082.1 | thermonuclease family protein | - |
| MUO45_RS13475 (MUO45_13440) | 2699240..2699440 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| MUO45_RS13480 (MUO45_13445) | 2699531..2699593 | - | 63 | Protein_2614 | hypothetical protein | - |
| MUO45_RS13485 (MUO45_13450) | 2699612..2700931 | - | 1320 | WP_001808146.1 | ISL3-like element IS1181 family transposase | - |
| MUO45_RS13490 (MUO45_13455) | 2701456..2701674 | - | 219 | WP_000005884.1 | hypothetical protein | - |
| MUO45_RS13495 (MUO45_13460) | 2701736..2702020 | - | 285 | WP_001004394.1 | hypothetical protein | - |
| MUO45_RS13500 (MUO45_13465) | 2702108..2702677 | - | 570 | WP_001106653.1 | lipoprotein N-acylation protein LnsA | - |
| MUO45_RS13505 (MUO45_13470) | 2702865..2703053 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| MUO45_RS13510 (MUO45_13475) | 2703082..2703342 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| MUO45_RS13515 (MUO45_13480) | 2703683..2703886 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| MUO45_RS13520 (MUO45_13485) | 2703883..2704119 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| MUO45_RS13525 (MUO45_13490) | 2704344..2704925 | + | 582 | WP_001140697.1 | histidine phosphatase family protein | - |
| MUO45_RS13530 (MUO45_13495) | 2704998..2705615 | - | 618 | WP_000255553.1 | LysE/ArgO family amino acid transporter | - |
| MUO45_RS13535 (MUO45_13500) | 2705770..2706264 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| MUO45_RS13540 (MUO45_13505) | 2706663..2707085 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| MUO45_RS13545 (MUO45_13510) | 2707233..2707949 | + | 717 | WP_000150013.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 2699612..2700931 | 1319 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T240773 WP_000052076.1 NZ_CP094926:c2703053-2702865 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T240773 NZ_LT703505:1259710-1260171 [Mycobacterium intracellulare subsp. chimaera]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACTATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACTATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT240773 WP_001059690.1 NZ_CP094926:c2703342-2703082 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT240773 NZ_LT703505:1259518-1259706 [Mycobacterium intracellulare subsp. chimaera]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCGGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCGGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |