Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1512305..1513096 Replicon chromosome
Accession NZ_CP094926
Organism Staphylococcus aureus strain 14

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag MUO45_RS07810 Protein ID WP_000525007.1
Coordinates 1512632..1513096 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag MUO45_RS07805 Protein ID WP_000333630.1
Coordinates 1512305..1512619 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO45_RS07750 (MUO45_07725) 1507688..1508239 - 552 WP_000704705.1 single-stranded DNA-binding protein -
MUO45_RS07755 (MUO45_07730) 1508268..1509056 - 789 WP_000134097.1 ATP-binding protein -
MUO45_RS07760 (MUO45_07735) 1509049..1509270 - 222 WP_000815401.1 DUF2483 family protein -
MUO45_RS07765 (MUO45_07740) 1509280..1509540 - 261 WP_107386909.1 DUF1108 family protein -
MUO45_RS07770 (MUO45_07745) 1509632..1509793 - 162 WP_000066021.1 DUF1270 family protein -
MUO45_RS07775 (MUO45_07750) 1509805..1510068 - 264 WP_001124198.1 helix-turn-helix domain-containing protein -
MUO45_RS07780 (MUO45_07755) 1510218..1510316 - 99 Protein_1498 hypothetical protein -
MUO45_RS07785 (MUO45_07760) 1510332..1511081 - 750 WP_001148586.1 phage antirepressor KilAC domain-containing protein -
MUO45_RS07790 (MUO45_07765) 1511141..1511623 + 483 WP_000394410.1 hypothetical protein -
MUO45_RS07795 (MUO45_07770) 1511724..1511903 - 180 WP_000438352.1 hypothetical protein -
MUO45_RS07800 (MUO45_07775) 1511917..1512153 - 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
MUO45_RS07805 (MUO45_07780) 1512305..1512619 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
MUO45_RS07810 (MUO45_07785) 1512632..1513096 + 465 WP_000525007.1 hypothetical protein Toxin
MUO45_RS07815 (MUO45_07790) 1513128..1514060 + 933 WP_000392183.1 hypothetical protein -
MUO45_RS07820 (MUO45_07795) 1514040..1514219 - 180 WP_000337827.1 hypothetical protein -
MUO45_RS07825 (MUO45_07800) 1514330..1515535 + 1206 WP_000264186.1 tyrosine-type recombinase/integrase -
MUO45_RS07830 (MUO45_07805) 1515629..1515724 - 96 Protein_1508 QueT transporter family protein -
MUO45_RS07835 (MUO45_07810) 1515735..1516427 - 693 WP_000286877.1 6-carboxyhexanoate--CoA ligase -
MUO45_RS07840 (MUO45_07815) 1516438..1517553 - 1116 WP_024273594.1 pyridoxal phosphate-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgC / hlgB 1466769..1527986 61217


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T240769 WP_000525007.1 NZ_CP094926:1512632-1513096 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T240769 NZ_LT703505:c288579-288019 [Mycobacterium intracellulare subsp. chimaera]
GTGAGCGATGCCCTCGACGAAGGGCTCGTCCAGCGCATCGACGCATGCGGCACCACTCCGTGGTCAGGCACGTGCTATCG
GTACACGACAGCTCATCGCGACGCACTCTCCGGCGAAGGCGCACGACGGTTCGGTGGCCGATGGAACCCACCACTGCTCT
TCCCCGCCATCTACCTTGCCGACTCCGCCAAGGCTTGCATGGTCGAAGTCGAACGCGCCGCCAACGCGGCCTCCACCACC
GCAATAAAGATGCTGGAGGCGGCCTACCGACTGCACCACATCCAGGTCGAGGAACTCAACGTTCTCGACTTGCGCACACC
CGAATCTCGAGACGCCGTCGGTCTCGACGACGACGACGTCTACGGTGACGACTGGTCCGCCTGCCAAGCAGTCGGACACA
CCGCCTGGTTCCTGCACATGCAAGGGATCCTGGTCCCCGCCGCCGGCGGCATCGGCCTCGTCATCTCCGCCTATGAACAG
CGAACGCGCCCAAGACAACTGCATCTCAGGCACAGCGAAAACCTCACCCCGGCGCTCTACACCCAATACCGCTCCAGCTA
A

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT240769 WP_000333630.1 NZ_CP094926:1512305-1512619 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT240769 NZ_LT703505:c288917-288576 [Mycobacterium intracellulare subsp. chimaera]
ATGGCAATGAATGCGCTCGCCTCGACCGTTTCGAGCGCCATCGAACGCCTGGGACTCACCTACGAAGAAGTCGGAGACAT
CGTCGAGGCCTCCCCACGCTCCGTGGCGCGGTGGACGTCGGGCCAAGTAGTTCCACAACGACTAAACAAGCAACGTCTGA
TCGAACTGGCTTACGTTGCCGATGCCCTTGCCGAAGTCCTCCCTCGCGACCAGGCGAATATGTGGATGTTCTCGCCGAAC
CGACTACTAGAGCACCGCAAGCCGGCCGACCTCATCCGAGATGGCGAATACCAGCGAGTGCTAGCCCTCATCGACGCCAT
GGCCGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References