Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 2838172..2838969 | Replicon | chromosome |
| Accession | NZ_CP094925 | ||
| Organism | Staphylococcus aureus strain 15 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | MUO48_RS14130 | Protein ID | WP_000525004.1 |
| Coordinates | 2838172..2838633 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUO48_RS14135 | Protein ID | WP_001260485.1 |
| Coordinates | 2838646..2838969 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO48_RS14100 (MUO48_14090) | 2834026..2834829 | + | 804 | WP_000928413.1 | TerC family protein | - |
| MUO48_RS14105 (MUO48_14095) | 2835118..2836323 | - | 1206 | WP_000264741.1 | site-specific integrase | - |
| MUO48_RS14110 (MUO48_14100) | 2836449..2837063 | + | 615 | WP_000191466.1 | hypothetical protein | - |
| MUO48_RS14115 (MUO48_14105) | 2837060..2837206 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| MUO48_RS14120 (MUO48_14110) | 2837296..2837691 | - | 396 | WP_000449655.1 | hypothetical protein | - |
| MUO48_RS14125 (MUO48_14115) | 2837720..2838154 | - | 435 | WP_000755719.1 | hypothetical protein | - |
| MUO48_RS14130 (MUO48_14120) | 2838172..2838633 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| MUO48_RS14135 (MUO48_14125) | 2838646..2838969 | - | 324 | WP_001260485.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUO48_RS14140 (MUO48_14130) | 2839133..2839381 | + | 249 | WP_000272860.1 | helix-turn-helix transcriptional regulator | - |
| MUO48_RS14145 (MUO48_14135) | 2839397..2839642 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MUO48_RS14150 (MUO48_14140) | 2839611..2839976 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| MUO48_RS14155 (MUO48_14145) | 2840031..2840246 | + | 216 | WP_001036302.1 | hypothetical protein | - |
| MUO48_RS14160 (MUO48_14150) | 2840271..2840534 | + | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| MUO48_RS14165 (MUO48_14155) | 2840547..2840708 | + | 162 | WP_001285963.1 | DUF1270 family protein | - |
| MUO48_RS14170 (MUO48_14160) | 2840787..2841110 | + | 324 | WP_000174994.1 | hypothetical protein | - |
| MUO48_RS14175 (MUO48_14165) | 2841125..2841487 | + | 363 | WP_150868153.1 | hypothetical protein | - |
| MUO48_RS14180 (MUO48_14170) | 2841484..2842650 | + | 1167 | WP_277445891.1 | DUF2800 domain-containing protein | - |
| MUO48_RS14185 (MUO48_14175) | 2842677..2843231 | + | 555 | WP_000647288.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2835118..2856239 | 21121 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T240761 WP_000525004.1 NZ_CP094925:c2838633-2838172 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T240761 NZ_LT671859:c2451589-2451323 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12439.16 Da Isoelectric Point: 9.3811
>AT240761 WP_001260485.1 NZ_CP094925:c2838969-2838646 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT240761 NZ_LT671859:c2451840-2451589 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|