Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2702874..2703351 Replicon chromosome
Accession NZ_CP094925
Organism Staphylococcus aureus strain 15

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUO48_RS13450 Protein ID WP_000052076.1
Coordinates 2702874..2703062 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUO48_RS13455 Protein ID WP_001059690.1
Coordinates 2703091..2703351 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO48_RS13415 (MUO48_13405) 2698205..2698891 + 687 WP_001548082.1 thermonuclease family protein -
MUO48_RS13420 (MUO48_13410) 2699249..2699449 + 201 WP_001059082.1 cold-shock protein -
MUO48_RS13425 (MUO48_13415) 2699540..2699602 - 63 Protein_2603 hypothetical protein -
MUO48_RS13430 (MUO48_13420) 2699621..2700940 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -
MUO48_RS13435 (MUO48_13425) 2701465..2701683 - 219 WP_000005884.1 hypothetical protein -
MUO48_RS13440 (MUO48_13430) 2701745..2702029 - 285 WP_001004394.1 hypothetical protein -
MUO48_RS13445 (MUO48_13435) 2702117..2702686 - 570 WP_001106653.1 lipoprotein N-acylation protein LnsA -
MUO48_RS13450 (MUO48_13440) 2702874..2703062 - 189 WP_000052076.1 hypothetical protein Toxin
MUO48_RS13455 (MUO48_13445) 2703091..2703351 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUO48_RS13460 (MUO48_13450) 2703692..2703895 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUO48_RS13465 (MUO48_13455) 2703892..2704128 - 237 WP_000368687.1 hypothetical protein -
MUO48_RS13470 (MUO48_13460) 2704353..2704934 + 582 WP_001140697.1 histidine phosphatase family protein -
MUO48_RS13475 (MUO48_13465) 2705007..2705624 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
MUO48_RS13480 (MUO48_13470) 2705779..2706273 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MUO48_RS13485 (MUO48_13475) 2706672..2707094 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
MUO48_RS13490 (MUO48_13480) 2707242..2707958 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2699621..2700940 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240760 WP_000052076.1 NZ_CP094925:c2703062-2702874 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240760 NZ_LT671859:c2186587-2186483 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240760 WP_001059690.1 NZ_CP094925:c2703351-2703091 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240760 NZ_LT671859:2186389-2186427 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References