Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1511892..1512683 Replicon chromosome
Accession NZ_CP094925
Organism Staphylococcus aureus strain 15

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag MUO48_RS07775 Protein ID WP_000525007.1
Coordinates 1512219..1512683 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag MUO48_RS07770 Protein ID WP_000333630.1
Coordinates 1511892..1512206 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO48_RS07715 (MUO48_07710) 1507275..1507826 - 552 WP_000704705.1 single-stranded DNA-binding protein -
MUO48_RS07720 (MUO48_07715) 1507855..1508643 - 789 WP_000134097.1 ATP-binding protein -
MUO48_RS07725 (MUO48_07720) 1508636..1508857 - 222 WP_000815401.1 DUF2483 family protein -
MUO48_RS07730 (MUO48_07725) 1508867..1509127 - 261 WP_107386909.1 DUF1108 family protein -
MUO48_RS07735 (MUO48_07730) 1509219..1509380 - 162 WP_000066021.1 DUF1270 family protein -
MUO48_RS07740 (MUO48_07735) 1509392..1509655 - 264 WP_001124198.1 helix-turn-helix domain-containing protein -
MUO48_RS07745 (MUO48_07740) 1509805..1509903 - 99 Protein_1491 hypothetical protein -
MUO48_RS07750 (MUO48_07745) 1509919..1510668 - 750 WP_001148586.1 phage antirepressor KilAC domain-containing protein -
MUO48_RS07755 (MUO48_07750) 1510728..1511210 + 483 WP_000394410.1 hypothetical protein -
MUO48_RS07760 (MUO48_07755) 1511311..1511490 - 180 WP_000438352.1 hypothetical protein -
MUO48_RS07765 (MUO48_07760) 1511504..1511740 - 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
MUO48_RS07770 (MUO48_07765) 1511892..1512206 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
MUO48_RS07775 (MUO48_07770) 1512219..1512683 + 465 WP_000525007.1 hypothetical protein Toxin
MUO48_RS07780 (MUO48_07775) 1512715..1513647 + 933 WP_000392183.1 hypothetical protein -
MUO48_RS07785 (MUO48_07780) 1513627..1513806 - 180 WP_000337827.1 hypothetical protein -
MUO48_RS07790 (MUO48_07785) 1513917..1515122 + 1206 WP_000264186.1 tyrosine-type recombinase/integrase -
MUO48_RS07795 (MUO48_07790) 1515216..1515311 - 96 Protein_1501 QueT transporter family protein -
MUO48_RS07800 (MUO48_07795) 1515322..1516014 - 693 WP_277558600.1 6-carboxyhexanoate--CoA ligase -
MUO48_RS07805 (MUO48_07800) 1516025..1517140 - 1116 WP_024273594.1 pyridoxal phosphate-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgC / hlgB 1466356..1525454 59098


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T240756 WP_000525007.1 NZ_CP094925:1512219-1512683 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T240756 NZ_LT671859:c1906829-1906677 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAGAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT240756 WP_000333630.1 NZ_CP094925:1511892-1512206 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT240756 NZ_LT671859:c1907453-1906854 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References