Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1144562..1145076 Replicon chromosome
Accession NZ_CP094925
Organism Staphylococcus aureus strain 15

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUO48_RS05725 Protein ID WP_000581792.1
Coordinates 1144562..1144771 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MUO48_RS05730 Protein ID WP_000138932.1
Coordinates 1144783..1145076 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO48_RS05705 (MUO48_05695) 1140070..1141428 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUO48_RS05710 (MUO48_05700) 1141443..1142513 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUO48_RS05715 (MUO48_05705) 1142831..1144033 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUO48_RS05720 (MUO48_05710) 1144297..1144434 - 138 WP_000828354.1 Lmo0850 family protein -
MUO48_RS05725 (MUO48_05715) 1144562..1144771 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUO48_RS05730 (MUO48_05720) 1144783..1145076 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUO48_RS05735 (MUO48_05725) 1145242..1146726 + 1485 WP_000571549.1 cardiolipin synthase -
MUO48_RS05740 (MUO48_05730) 1146754..1147401 + 648 WP_001187630.1 HD domain-containing protein -
MUO48_RS05745 (MUO48_05735) 1148006..1148878 - 873 WP_000725802.1 membrane protein insertase YidC -
MUO48_RS05750 (MUO48_05740) 1148964..1149605 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240754 WP_000581792.1 NZ_CP094925:c1144771-1144562 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240754 NZ_LT671859:c842452-842264 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT240754 WP_000138932.1 NZ_CP094925:c1145076-1144783 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240754 NZ_LT671859:c842741-842481 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References