Detailed information of TA system TA240752

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 957459..958235
• Replicon: chromosome
• Accession: NZ_CP094925
• Organism: Staphylococcus aureus strain 15

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: X5E2E6
• Locus tag: MUO48_RS04675
• Protein ID: WP_000031108.1
• Coordinates: 957459..957611 (-)
• Length: 51 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: W8U4V4
• Locus tag: MUO48_RS04680
• Protein ID: WP_001251224.1
• Coordinates: 957636..958235 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO48_RS04660 (MUO48_04650)	953666..954487	+	822	WP_000669376.1	RluA family pseudouridine synthase	-
MUO48_RS04665 (MUO48_04655)	954939..956324	-	1386	WP_000116229.1	class II fumarate hydratase	-
MUO48_RS04670 (MUO48_04660)	956520..956915	-	396	WP_000901023.1	hypothetical protein	-
MUO48_RS04675 (MUO48_04665)	957459..957611	-	153	WP_000031108.1	SAS053 family protein	Toxin
MUO48_RS04680 (MUO48_04670)	957636..958235	-	600	WP_001251224.1	glucosamine-6-phosphate isomerase	Antitoxin
MUO48_RS04685 (MUO48_04675)	958394..958864	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
MUO48_RS04690 (MUO48_04680)	958869..959996	-	1128	WP_000379980.1	tRNA epoxyqueuosine(34) reductase QueG	-
MUO48_RS04695 (MUO48_04685)	960148..960870	-	723	WP_000590809.1	amino acid ABC transporter ATP-binding protein	-
MUO48_RS04700 (MUO48_04690)	960863..962320	-	1458	WP_000649907.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5936.28 Da
• Isoelectric Point: 3.8962

>T240752 WP_000031108.1 NZ_CP094925:c957611-957459 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Nucleotide

• Length: 153 bp

>T240752 NZ_LT635480:c1363285-1363019 [Ndongobacter massiliensis]
ATGAAGAAGTATGAAATTGAATTGACAGAACGATTCAAAAAAGACTTCAGAAAGCTCGACCGATATACGCAGAAAATCAT
CCGAGCCTGGATGAACAAAAATCTTGTTGCATGTGAAAATCCTCGTCAACACGGGAAAGGACTCACCGCGAACAGAAGTG
GACAATGGCGCTATCGGATAGGAAGTTATCGTCTTATTGCCACAATTGACGACAATAAGCTTATCATTTTAGCTCTTTCC
GTCGGACATCGCAGGGAAATATATTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22343.47 Da
• Isoelectric Point: 5.1445

>AT240752 WP_001251224.1 NZ_CP094925:c958235-957636 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT240752 NZ_LT635480:c1363499-1363272 [Ndongobacter massiliensis]
ATGGCATTTTCCATCCGTTTAACCGAAGAAGAGCGCAAACTCGCTACCGCCTATGCGCGTTTACACGGGGTATCGGTGGG
CGAGGCGTTCAAGCAGGCGCTGTTTGAACGTATCGAAGATGAGTACGACCTCGCTGTAGCGGAAGAAGCATATCGTGAGT
ACTTAGAAAGCGGGTGTCAATCCACTCCCATTGAAGAGTTTTGGAGGGAATTGGATGAAGAAGTATGA

Structures

Toxin

• AlphaFold DB: X5E2E6

Antitoxin

• AlphaFold DB: W8U4V4