Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 2852609..2853406 | Replicon | chromosome |
| Accession | NZ_CP094924 | ||
| Organism | Staphylococcus aureus strain 18 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | MUO49_RS14235 | Protein ID | WP_000525004.1 |
| Coordinates | 2852609..2853070 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUO49_RS14240 | Protein ID | WP_277558125.1 |
| Coordinates | 2853083..2853406 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO49_RS14205 (MUO49_14190) | 2848462..2849265 | + | 804 | WP_000928413.1 | TerC family protein | - |
| MUO49_RS14210 (MUO49_14195) | 2849554..2850759 | - | 1206 | WP_000264741.1 | site-specific integrase | - |
| MUO49_RS14215 (MUO49_14200) | 2850885..2851499 | + | 615 | WP_000191466.1 | hypothetical protein | - |
| MUO49_RS14220 (MUO49_14205) | 2851496..2851642 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| MUO49_RS14225 (MUO49_14210) | 2851733..2852128 | - | 396 | WP_000449655.1 | hypothetical protein | - |
| MUO49_RS14230 (MUO49_14215) | 2852157..2852591 | - | 435 | WP_000755719.1 | hypothetical protein | - |
| MUO49_RS14235 (MUO49_14220) | 2852609..2853070 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| MUO49_RS14240 (MUO49_14225) | 2853083..2853406 | - | 324 | WP_277558125.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUO49_RS14245 (MUO49_14230) | 2853570..2853818 | + | 249 | WP_000272860.1 | helix-turn-helix transcriptional regulator | - |
| MUO49_RS14250 (MUO49_14235) | 2853834..2854079 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MUO49_RS14255 (MUO49_14240) | 2854048..2854413 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| MUO49_RS14260 (MUO49_14245) | 2854468..2854683 | + | 216 | WP_001036302.1 | hypothetical protein | - |
| MUO49_RS14265 (MUO49_14250) | 2854708..2854971 | + | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| MUO49_RS14270 (MUO49_14255) | 2854984..2855145 | + | 162 | WP_001285963.1 | DUF1270 family protein | - |
| MUO49_RS14275 (MUO49_14260) | 2855224..2855547 | + | 324 | WP_000174994.1 | hypothetical protein | - |
| MUO49_RS14280 (MUO49_14265) | 2855562..2855924 | + | 363 | WP_150868153.1 | hypothetical protein | - |
| MUO49_RS14285 (MUO49_14270) | 2855921..2857087 | + | 1167 | WP_277445891.1 | DUF2800 domain-containing protein | - |
| MUO49_RS14290 (MUO49_14275) | 2857114..2857668 | + | 555 | WP_000647288.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2849554..2870676 | 21122 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T240748 WP_000525004.1 NZ_CP094924:c2853070-2852609 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T240748 NZ_LT634361:45650-45952 [Tenacibaculum maritimum NCIMB 2154]
ATGAGTAAAAACAAATATCGCATAAGTCAACAAGCGATTGAGGATTTAGATAACATTTGGATTTATACACTTAACAAATG
GTCTAAAGAACAAGCTGATAGATATTACGACTTGATAATTACGGAGATTGAATTTATTGCTGATAACTTTATGACAGGAA
AGTCAGCAGAACAAACTCGAAAGAATTATCGAGTGACTAAGATAAAATCACATCTGATTTTTTATAGAAAAATGGAAAAT
GATATTGTGGAAATTGTTAGAGTTTTACACCAACGAATGGATGTTAAAAAGCGACTGAAATAA
ATGAGTAAAAACAAATATCGCATAAGTCAACAAGCGATTGAGGATTTAGATAACATTTGGATTTATACACTTAACAAATG
GTCTAAAGAACAAGCTGATAGATATTACGACTTGATAATTACGGAGATTGAATTTATTGCTGATAACTTTATGACAGGAA
AGTCAGCAGAACAAACTCGAAAGAATTATCGAGTGACTAAGATAAAATCACATCTGATTTTTTATAGAAAAATGGAAAAT
GATATTGTGGAAATTGTTAGAGTTTTACACCAACGAATGGATGTTAAAAAGCGACTGAAATAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12455.20 Da Isoelectric Point: 9.3811
>AT240748 WP_277558125.1 NZ_CP094924:c2853406-2853083 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQLENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQLENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT240748 NZ_LT634361:45411-45653 [Tenacibaculum maritimum NCIMB 2154]
ATGGGAAAAAACACATCAATATCACTCGGAAATCATTTTGAGGATTTTATCAGAGAAGAAGTAAAATCTGGAAGATATGG
TTCCGTTAGCGAAGTAATTCGTTCCGCATTACGTTTATTGGAACGAGAAGAAAAAAAAGAAAGAGAACTGATTAAAGCTC
TTGAAGTTGGAGAAAATAGCGGATTTGTTGAAAATTTTGACCCAAAACAACATCTGAAAGAATTACATCGGAAACACTTA
TGA
ATGGGAAAAAACACATCAATATCACTCGGAAATCATTTTGAGGATTTTATCAGAGAAGAAGTAAAATCTGGAAGATATGG
TTCCGTTAGCGAAGTAATTCGTTCCGCATTACGTTTATTGGAACGAGAAGAAAAAAAAGAAAGAGAACTGATTAAAGCTC
TTGAAGTTGGAGAAAATAGCGGATTTGTTGAAAATTTTGACCCAAAACAACATCTGAAAGAATTACATCGGAAACACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|