Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2717310..2717787 Replicon chromosome
Accession NZ_CP094924
Organism Staphylococcus aureus strain 18

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag MUO49_RS13555 Protein ID WP_000052076.1
Coordinates 2717310..2717498 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag MUO49_RS13560 Protein ID WP_001059690.1
Coordinates 2717527..2717787 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO49_RS13520 (MUO49_13505) 2712641..2713327 + 687 WP_001548082.1 thermonuclease family protein -
MUO49_RS13525 (MUO49_13510) 2713685..2713885 + 201 WP_001059082.1 cold-shock protein -
MUO49_RS13530 (MUO49_13515) 2713976..2714038 - 63 Protein_2624 hypothetical protein -
MUO49_RS13535 (MUO49_13520) 2714057..2715376 - 1320 WP_001808146.1 ISL3-like element IS1181 family transposase -
MUO49_RS13540 (MUO49_13525) 2715901..2716119 - 219 WP_000005884.1 hypothetical protein -
MUO49_RS13545 (MUO49_13530) 2716181..2716465 - 285 WP_001004394.1 hypothetical protein -
MUO49_RS13550 (MUO49_13535) 2716553..2717122 - 570 WP_001106653.1 lipoprotein N-acylation protein LnsA -
MUO49_RS13555 (MUO49_13540) 2717310..2717498 - 189 WP_000052076.1 hypothetical protein Toxin
MUO49_RS13560 (MUO49_13545) 2717527..2717787 - 261 WP_001059690.1 hypothetical protein Antitoxin
MUO49_RS13565 (MUO49_13550) 2718128..2718331 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
MUO49_RS13570 (MUO49_13555) 2718328..2718564 - 237 WP_000368687.1 hypothetical protein -
MUO49_RS13575 (MUO49_13560) 2718789..2719370 + 582 WP_001140697.1 histidine phosphatase family protein -
MUO49_RS13580 (MUO49_13565) 2719443..2720060 - 618 WP_000255553.1 LysE/ArgO family amino acid transporter -
MUO49_RS13585 (MUO49_13570) 2720215..2720709 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
MUO49_RS13590 (MUO49_13575) 2721108..2721530 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
MUO49_RS13595 (MUO49_13580) 2721678..2722394 + 717 WP_000150013.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2714057..2715376 1319


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(13-264)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(97-254)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T240747 WP_000052076.1 NZ_CP094924:c2717498-2717310 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T240747 NZ_LT632617:c2187929-2186997 [Legionella pneumophila]
ATGAATAAACAGTCACCATATTATAAACAGGTTTTGTTGCTCATTCGTTTAATTCCACTCGTCGAAAAGGAAACTTGTTT
TGCTTTAAAGGGAGGTACTGCCATTAATTTATTTGTGCGAGATTTCCCGAGGTTATCTGTGGATATAGATCTAGCGTATT
TACCCCTCGAGCCACGTGAGATTGCTTTAGCCAATGTGCGTAATGCATTAGCGGGTATTGCGGCAAATATTAATAAAATT
CCAGATTTGAATGCAGTTTTGCAAGATAACAAACCAGATGAAATGCGAATTATTGTTGAAGATCATTCTTCTCTAAATAG
GGGGACCCAAATCAAGATAGAAGTTTCACCTGTTGCGCGTGGAACTCTTTTGCCGCCAGTTGAGCTTGATGTTGTTGCTT
CGGTGGAAAATGAGTTTGGTTTTGCGTCAATGAAAGTCGTTTCTTTGCCTGATCTCTATGGTGGTAAATTATGCGCTGCT
TTAGATCGCCAGCATCCTAGAGATCTTTTTGATGTTAAGGTTTTGTTAGAAAATCAAAAGATTGACCGAGAGCTTTTTAA
TGGGTTTCTTACTTATCTTTTAAGTCACAAAAGGCCTATTTCAGAAATAATGAATCCACGATGGAAAGATATAACTCAAG
TTTTTGAACGTGAATTTAAAGGAATGACTGCTGAACCAGTTACCCTGGAAGAGCTAACAGCAATACCAGGAAAAATGATT
CAGGGTCTTAAAGATAATTTTACTCAGCAGGATTATGATTTTTTAGTCTCTTTTAAAAGGGGCGAGCCTGAGTGGTCTCT
TGCATGTAGCGATCAGATTCAATATCTCCCAGCAGTACAATGGAAGCTTTTAAATATTCGCAAAATGCCCAAACAAAAAC
TCATGGATTCAGTTAGCTTGCTACAAAGAACGATGGGACATTGGCTTAATTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT240747 WP_001059690.1 NZ_CP094924:c2717787-2717527 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT240747 NZ_LT632617:c2188718-2187933 [Legionella pneumophila]
ATGTCATCAAAAATAAACTGGCTTCTGAATAATATTGCCTCAGGTGAAATCTTGCTCCAGTCTTGGTTATCAAGCCATGG
AATTACTCCACAATTAGCAAGAAAATATTGTCAAAGCCAATGGTTGGTAAAATTGGGGGTAGGGGTTTATTATCGTGCAG
GGCGTAAACCTAGATGGCAAAATGCAGTTTATTGTCTTCAGAATCAGAGTCGGTACATGATTCATCTTGCTGGTTTAACC
AGTTTGGCTCAGCAGGGCAAATCGCATTACCTACAGTTTGCACCAGACTCTATTTGGATAAACGTTCAAGCAAAAACGAT
TTTACCAAAGTGGTTTAAAAATTTTCCAGAATTAGTTATTTCTGATGAACTAATACCAAATTGGGAAATCATTAAAACAT
CCAAGTTAAATGCTCAGGATGAGAATGACTTAACTACTATAGAAGTAGATGGGATTAAGTTAAAAGCAAGTAATCAAGAG
TTAGCCGCATTCGAGGTGCTGGAGGCTGTACCTTCCACTTTGTCATTTGAGCATGCAGCAGAGCTTTTTCAAGGATTGGT
AAACTTAAGTCCACGAAAAGTAGAACATATTTTAAAAAGAAGCGGATCTATTCAAACGAACCGACTTTTTTTATTTTTGG
GTCATTTCTATAAACATCCATGGGCTGAACGGGTGAATGAGTCCTTAATTAATCTTGGTGCAGGTAAGCGTCAAATAGTC
CCTGATGGAAAATTAGAAAAACAATATCAAATCACCGTTCCAGAACAATTTATAAGTAGCGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References