Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1526453..1527244 Replicon chromosome
Accession NZ_CP094924
Organism Staphylococcus aureus strain 18

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag MUO49_RS07875 Protein ID WP_000525007.1
Coordinates 1526780..1527244 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag MUO49_RS07870 Protein ID WP_000333630.1
Coordinates 1526453..1526767 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO49_RS07815 (MUO49_07805) 1521836..1522387 - 552 WP_000704705.1 single-stranded DNA-binding protein -
MUO49_RS07820 (MUO49_07810) 1522416..1523204 - 789 WP_000134097.1 ATP-binding protein -
MUO49_RS07825 (MUO49_07815) 1523197..1523418 - 222 WP_000815401.1 DUF2483 family protein -
MUO49_RS07830 (MUO49_07820) 1523428..1523688 - 261 WP_107386909.1 DUF1108 family protein -
MUO49_RS07835 (MUO49_07825) 1523780..1523941 - 162 WP_000066021.1 DUF1270 family protein -
MUO49_RS07840 (MUO49_07830) 1523953..1524216 - 264 WP_001124198.1 helix-turn-helix domain-containing protein -
MUO49_RS07845 (MUO49_07835) 1524366..1524464 - 99 Protein_1511 hypothetical protein -
MUO49_RS07850 (MUO49_07840) 1524480..1525229 - 750 WP_001148586.1 phage antirepressor KilAC domain-containing protein -
MUO49_RS07855 (MUO49_07845) 1525289..1525771 + 483 WP_000394410.1 hypothetical protein -
MUO49_RS07860 (MUO49_07850) 1525872..1526051 - 180 WP_000438352.1 hypothetical protein -
MUO49_RS07865 (MUO49_07855) 1526065..1526301 - 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
MUO49_RS07870 (MUO49_07860) 1526453..1526767 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
MUO49_RS07875 (MUO49_07865) 1526780..1527244 + 465 WP_000525007.1 hypothetical protein Toxin
MUO49_RS07880 (MUO49_07870) 1527276..1528208 + 933 WP_000392183.1 hypothetical protein -
MUO49_RS07885 (MUO49_07875) 1528188..1528367 - 180 WP_000337827.1 hypothetical protein -
MUO49_RS07890 (MUO49_07880) 1528478..1529683 + 1206 WP_000264186.1 tyrosine-type recombinase/integrase -
MUO49_RS07895 (MUO49_07885) 1529777..1529872 - 96 Protein_1521 QueT transporter family protein -
MUO49_RS07900 (MUO49_07890) 1529883..1530575 - 693 WP_000286877.1 6-carboxyhexanoate--CoA ligase -
MUO49_RS07905 (MUO49_07895) 1530586..1531701 - 1116 WP_024273594.1 pyridoxal phosphate-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgC / hlgB 1480918..1540015 59097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T240743 WP_000525007.1 NZ_CP094924:1526780-1527244 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T240743 NZ_LT632614:c1242980-1242474 [Legionella pneumophila]
ATGGTTGATAATTCAATAATAACAATAAATGGCTGGGTTATTTTATGCCATCCTCTTTTTTTGCAACAGGTAGAGGCATT
GGCTAATGAGGTAGAAAAAGCAAAAGAAAAGGACCCTTCAAATTTTCATACACGAAACTCGACAAAAAAATTAGCAGCCA
TTGCTAAATTAGCTTTTGAAAAAATTCCAAACGATCCTGCAGCTACAGAATTTCGACAAGGATCAACATTAGGAAATAAC
CACAAACATTGGTTTCGAGCTAAATTTTTTCAGCAATATCGATTATTTTTTAGATACCATCAAGAAAGTAAAATAATTAT
TTATGCTTGGGTTAATGATGACAGTTCTAAAAGAGCATATGAAAGTAAAGCAGATGCTTATCATATTTTTCGAAAGATGC
TGGAAAATGGTCATCCTCCAGATAATTGGGATGAATTACTTAAAGAAGCAAATAACACTTCGTTAATGAAAAAATTGACT
ACCAGTTTGGATGCTTTGAAAAGTTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT240743 WP_000333630.1 NZ_CP094924:1526453-1526767 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT240743 NZ_LT632614:c1243327-1242980 [Legionella pneumophila]
ATGGCTAGATTACTACAAACCGAATCCACCCTCACAGATCGTTATCAAACAACTGTACCAGATGCTGTGAGAAAAGCCCT
GCATCTAGGAAAAAGAGATAAAATTCGATACACCGTTCAATCTGACGGTCATGTTCTTATGACTCGAGCAGAGAAAGAGG
AAGATCCAGTAATTGCTGAATTTTTGAATTTCATTGCTAAAGACATTCAAAATAACCCCAAAAATCTGACAACTATAAAT
CAGGATTTAGTAACTCGCATCAACTCTTTAGTTGCAAATGTTGAAGTCAATTTAGATGAACCTTTAACCGAGGATGAACA
ATTAACTGAAAACCGAGTAAGTCGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References