Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 957238..958014 Replicon chromosome
Accession NZ_CP094924
Organism Staphylococcus aureus strain 18

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag MUO49_RS04680 Protein ID WP_000031108.1
Coordinates 957238..957390 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag MUO49_RS04685 Protein ID WP_001251224.1
Coordinates 957415..958014 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO49_RS04665 (MUO49_04650) 953445..954266 + 822 WP_000669376.1 RluA family pseudouridine synthase -
MUO49_RS04670 (MUO49_04655) 954718..956103 - 1386 WP_000116229.1 class II fumarate hydratase -
MUO49_RS04675 (MUO49_04660) 956299..956694 - 396 WP_000901023.1 hypothetical protein -
MUO49_RS04680 (MUO49_04665) 957238..957390 - 153 WP_000031108.1 SAS053 family protein Toxin
MUO49_RS04685 (MUO49_04670) 957415..958014 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
MUO49_RS04690 (MUO49_04675) 958173..958643 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MUO49_RS04695 (MUO49_04680) 958648..959775 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
MUO49_RS04700 (MUO49_04685) 959927..960649 - 723 WP_000590809.1 amino acid ABC transporter ATP-binding protein -
MUO49_RS04705 (MUO49_04690) 960642..962099 - 1458 WP_000649907.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T240739 WP_000031108.1 NZ_CP094924:c957390-957238 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T240739 NZ_LT630450:2640141-2640473 [Desulfovibrio piger]
ATGCGGCGTGGTGATATTTATCTGGTGACGCTTGACCCTACAGAAGGGCATGAGCAGCAGGGAACGCGACCGGTGTTGGT
GATTTCTCCCGACGAGTTCAACAGAGTGACGCAGGTTCCCGTAGTGTTGCCGATTACCAGCGGGGGGAATTTTGCCCGTA
CCGCAGGATTCGCCGTGTCGCTCAGCGGATGCGGCACACGCACCACGGGAGTGATCCGTTGTGACCAGCCCAGGGCGCTG
GACTTGCGGGCGAGATCCGGCAGACGGCTGGAACAAGTACCGCCCGTCATTATGGATGAAGTTCTTGCAAGGTTGGCGAC
CATTTTCAGCTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT240739 WP_001251224.1 NZ_CP094924:c958014-957415 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT240739 NZ_LT630450:2639884-2640141 [Desulfovibrio piger]
ATGTACACAGCTAATTTGAGAAAAGTCGGCGGTTCAGTGATGCTGGCCGTTCCTCCCGCCATTTTGGAAATGCTGCAAAT
GGAATCGGGGTCATCGGTAAGCATGGCCGTGGAATCCGGGCGTCTGATTATTGAGCCGAACGTCAGGAAGAAGTACAGCC
TGCAGGAGCTGCTAGCCCAATGTGACCCTTCCGCGCCGCTTTCCTCTGAAGATGGTGTGTGGACAGGGTCGGGAGCCACG
GGCAGGGAGCTGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References