Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 2852783..2853580 | Replicon | chromosome |
| Accession | NZ_CP094923 | ||
| Organism | Staphylococcus aureus strain 1824 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | MUO47_RS14245 | Protein ID | WP_000525004.1 |
| Coordinates | 2852783..2853244 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | MUO47_RS14250 | Protein ID | WP_001260485.1 |
| Coordinates | 2853257..2853580 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUO47_RS14215 (MUO47_14200) | 2848636..2849439 | + | 804 | WP_000928413.1 | TerC family protein | - |
| MUO47_RS14220 (MUO47_14205) | 2849728..2850933 | - | 1206 | WP_000264741.1 | site-specific integrase | - |
| MUO47_RS14225 (MUO47_14210) | 2851059..2851673 | + | 615 | WP_000191466.1 | hypothetical protein | - |
| MUO47_RS14230 (MUO47_14215) | 2851670..2851816 | - | 147 | WP_001013104.1 | hypothetical protein | - |
| MUO47_RS14235 (MUO47_14220) | 2851907..2852302 | - | 396 | WP_000449655.1 | hypothetical protein | - |
| MUO47_RS14240 (MUO47_14225) | 2852331..2852765 | - | 435 | WP_000755719.1 | hypothetical protein | - |
| MUO47_RS14245 (MUO47_14230) | 2852783..2853244 | - | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| MUO47_RS14250 (MUO47_14235) | 2853257..2853580 | - | 324 | WP_001260485.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| MUO47_RS14255 (MUO47_14240) | 2853827..2853991 | + | 165 | WP_277519332.1 | hypothetical protein | - |
| MUO47_RS14260 (MUO47_14245) | 2854007..2854252 | + | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| MUO47_RS14265 (MUO47_14250) | 2854221..2854586 | - | 366 | WP_001128433.1 | hypothetical protein | - |
| MUO47_RS14270 (MUO47_14255) | 2854641..2854856 | + | 216 | WP_001036302.1 | hypothetical protein | - |
| MUO47_RS14275 (MUO47_14260) | 2854881..2855144 | + | 264 | WP_001124190.1 | helix-turn-helix domain-containing protein | - |
| MUO47_RS14280 (MUO47_14265) | 2855157..2855318 | + | 162 | WP_001285963.1 | DUF1270 family protein | - |
| MUO47_RS14285 (MUO47_14270) | 2855397..2855720 | + | 324 | WP_000174994.1 | hypothetical protein | - |
| MUO47_RS14290 (MUO47_14275) | 2855735..2856097 | + | 363 | WP_150868153.1 | hypothetical protein | - |
| MUO47_RS14295 (MUO47_14280) | 2856094..2857260 | + | 1167 | WP_277445891.1 | DUF2800 domain-containing protein | - |
| MUO47_RS14300 (MUO47_14285) | 2857287..2857841 | + | 555 | WP_000647288.1 | DUF2815 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2849728..2870849 | 21121 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T240735 WP_000525004.1 NZ_CP094923:c2853244-2852783 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T240735 NZ_LT630450:650279-650539 [Desulfovibrio piger]
ATGCTGCTGACCTGGACGCCCCAAGCGTGGGAAGATTATCTGTACTGGCAGGCTACCGACAAACGGACGGTGAAGCGCAT
CAATGAGCTGCTGCGTGATGCGCTCCGCAATCCGTTTGAAGGCCTTGGCAAGCCGGAGCCGCTCCGCTTTGACCTTGCGG
GATGCTGGTCCCGCCGCATCAATCAGGAGGACCGCCTCGTGTATCGCCTTGACGAGCAGGGGGCGGCCCTGATCGTCCTC
CAGTGCCGCTACCACTACTGA
ATGCTGCTGACCTGGACGCCCCAAGCGTGGGAAGATTATCTGTACTGGCAGGCTACCGACAAACGGACGGTGAAGCGCAT
CAATGAGCTGCTGCGTGATGCGCTCCGCAATCCGTTTGAAGGCCTTGGCAAGCCGGAGCCGCTCCGCTTTGACCTTGCGG
GATGCTGGTCCCGCCGCATCAATCAGGAGGACCGCCTCGTGTATCGCCTTGACGAGCAGGGGGCGGCCCTGATCGTCCTC
CAGTGCCGCTACCACTACTGA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12439.16 Da Isoelectric Point: 9.3811
>AT240735 WP_001260485.1 NZ_CP094923:c2853580-2853257 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFAIKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQPENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT240735 NZ_LT630450:650022-650276 [Desulfovibrio piger]
ATGTCGCAGGCCATCACCTACACCGAGGCACGGCAGAACCTTGCGGAAACCATGAACCGGGTCTGTGACCACCACGAACC
CGTCATCATCACGCGCCAGAAGTCTCCCTCCGTGGTATTGATGTCCCTGGAGGACTACAACGCCATCATGGAAACAGCCT
ACCTGCTGCGTTCCCCGGCCAATGCCGCCCGGTTGCGGGAAGCATTGCACGCCGCTGACGCGGGCAAGACGGTACAGCAT
GACCTTGAGGACTGA
ATGTCGCAGGCCATCACCTACACCGAGGCACGGCAGAACCTTGCGGAAACCATGAACCGGGTCTGTGACCACCACGAACC
CGTCATCATCACGCGCCAGAAGTCTCCCTCCGTGGTATTGATGTCCCTGGAGGACTACAACGCCATCATGGAAACAGCCT
ACCTGCTGCGTTCCCCGGCCAATGCCGCCCGGTTGCGGGAAGCATTGCACGCCGCTGACGCGGGCAAGACGGTACAGCAT
GACCTTGAGGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|