Detailed information of TA system TA240734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 2717674..2718151
• Replicon: chromosome
• Accession: NZ_CP094923
• Organism: Staphylococcus aureus strain 1824

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: MUO47_RS13565
• Protein ID: WP_000052076.1
• Coordinates: 2717674..2717862 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: T1Y6P8
• Locus tag: MUO47_RS13570
• Protein ID: WP_001059690.1
• Coordinates: 2717891..2718151 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUO47_RS13530 (MUO47_13515)	2713005..2713691	+	687	WP_001548082.1	thermonuclease family protein	-
MUO47_RS13535 (MUO47_13520)	2714049..2714249	+	201	WP_001059082.1	cold-shock protein	-
MUO47_RS13540 (MUO47_13525)	2714340..2714402	-	63	Protein_2626	hypothetical protein	-
MUO47_RS13545 (MUO47_13530)	2714421..2715740	-	1320	WP_001808146.1	ISL3-like element IS1181 family transposase	-
MUO47_RS13550 (MUO47_13535)	2716265..2716483	-	219	WP_000005884.1	hypothetical protein	-
MUO47_RS13555 (MUO47_13540)	2716545..2716829	-	285	WP_001004394.1	hypothetical protein	-
MUO47_RS13560 (MUO47_13545)	2716917..2717486	-	570	WP_001106653.1	lipoprotein N-acylation protein LnsA	-
MUO47_RS13565 (MUO47_13550)	2717674..2717862	-	189	WP_000052076.1	hypothetical protein	Toxin
MUO47_RS13570 (MUO47_13555)	2717891..2718151	-	261	WP_001059690.1	hypothetical protein	Antitoxin
MUO47_RS13575 (MUO47_13560)	2718492..2718695	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
MUO47_RS13580 (MUO47_13565)	2718692..2718928	-	237	WP_000368687.1	hypothetical protein	-
MUO47_RS13585 (MUO47_13570)	2719153..2719734	+	582	WP_001140697.1	histidine phosphatase family protein	-
MUO47_RS13590 (MUO47_13575)	2719807..2720424	-	618	WP_000255553.1	LysE/ArgO family amino acid transporter	-
MUO47_RS13595 (MUO47_13580)	2720579..2721073	-	495	WP_000569884.1	GNAT family N-acetyltransferase	-
MUO47_RS13600 (MUO47_13585)	2721472..2721894	-	423	WP_000974460.1	organic hydroperoxide resistance protein	-
MUO47_RS13605 (MUO47_13590)	2722042..2722758	+	717	WP_000150013.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2714421..2715740	1319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-69)

Antitoxin

• Toxin YoeB (5-86)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T240734 WP_000052076.1 NZ_CP094923:c2717862-2717674 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T240734 NZ_LT630450:650022-650276 [Desulfovibrio piger]
ATGTCGCAGGCCATCACCTACACCGAGGCACGGCAGAACCTTGCGGAAACCATGAACCGGGTCTGTGACCACCACGAACC
CGTCATCATCACGCGCCAGAAGTCTCCCTCCGTGGTATTGATGTCCCTGGAGGACTACAACGCCATCATGGAAACAGCCT
ACCTGCTGCGTTCCCCGGCCAATGCCGCCCGGTTGCGGGAAGCATTGCACGCCGCTGACGCGGGCAAGACGGTACAGCAT
GACCTTGAGGACTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9940.09 Da
• Isoelectric Point: 4.0624

>AT240734 WP_001059690.1 NZ_CP094923:c2718151-2717891 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Nucleotide

• Length: 261 bp

>AT240734 NZ_LT630450:650279-650539 [Desulfovibrio piger]
ATGCTGCTGACCTGGACGCCCCAAGCGTGGGAAGATTATCTGTACTGGCAGGCTACCGACAAACGGACGGTGAAGCGCAT
CAATGAGCTGCTGCGTGATGCGCTCCGCAATCCGTTTGAAGGCCTTGGCAAGCCGGAGCCGCTCCGCTTTGACCTTGCGG
GATGCTGGTCCCGCCGCATCAATCAGGAGGACCGCCTCGTGTATCGCCTTGACGAGCAGGGGGCGGCCCTGATCGTCCTC
CAGTGCCGCTACCACTACTGA

Structures

Toxin

• AlphaFold DB: A0A0E0VP18

Antitoxin

• AlphaFold DB: A0A0E0VN56