Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1526961..1527752 Replicon chromosome
Accession NZ_CP094923
Organism Staphylococcus aureus strain 1824

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag MUO47_RS07885 Protein ID WP_000525007.1
Coordinates 1527288..1527752 (+) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag MUO47_RS07880 Protein ID WP_000333630.1
Coordinates 1526961..1527275 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO47_RS07825 (MUO47_07815) 1522344..1522895 - 552 WP_000704705.1 single-stranded DNA-binding protein -
MUO47_RS07830 (MUO47_07820) 1522924..1523712 - 789 WP_000134097.1 ATP-binding protein -
MUO47_RS07835 (MUO47_07825) 1523705..1523926 - 222 WP_000815401.1 DUF2483 family protein -
MUO47_RS07840 (MUO47_07830) 1523936..1524196 - 261 WP_107386909.1 DUF1108 family protein -
MUO47_RS07845 (MUO47_07835) 1524288..1524449 - 162 WP_000066021.1 DUF1270 family protein -
MUO47_RS07850 (MUO47_07840) 1524461..1524724 - 264 WP_001124198.1 helix-turn-helix domain-containing protein -
MUO47_RS07855 (MUO47_07845) 1524874..1524972 - 99 Protein_1513 hypothetical protein -
MUO47_RS07860 (MUO47_07850) 1524988..1525737 - 750 WP_001148586.1 phage antirepressor KilAC domain-containing protein -
MUO47_RS07865 (MUO47_07855) 1525797..1526279 + 483 WP_000394410.1 hypothetical protein -
MUO47_RS07870 (MUO47_07860) 1526380..1526559 - 180 WP_000438352.1 hypothetical protein -
MUO47_RS07875 (MUO47_07865) 1526573..1526809 - 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
MUO47_RS07880 (MUO47_07870) 1526961..1527275 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
MUO47_RS07885 (MUO47_07875) 1527288..1527752 + 465 WP_000525007.1 hypothetical protein Toxin
MUO47_RS07890 (MUO47_07880) 1527784..1528716 + 933 WP_000392183.1 hypothetical protein -
MUO47_RS07895 (MUO47_07885) 1528696..1528875 - 180 WP_000337827.1 hypothetical protein -
MUO47_RS07900 (MUO47_07890) 1528986..1530191 + 1206 WP_000264186.1 tyrosine-type recombinase/integrase -
MUO47_RS07905 (MUO47_07895) 1530285..1530380 - 96 Protein_1523 QueT transporter family protein -
MUO47_RS07910 (MUO47_07900) 1530391..1531083 - 693 WP_000286877.1 6-carboxyhexanoate--CoA ligase -
MUO47_RS07915 (MUO47_07905) 1531094..1532209 - 1116 WP_024273594.1 pyridoxal phosphate-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sbi / hlgA / hlgC / hlgB 1474595..1542642 68047


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T240730 WP_000525007.1 NZ_CP094923:1527288-1527752 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T240730 NZ_LT615378:4349382-4349555 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT240730 WP_000333630.1 NZ_CP094923:1526961-1527275 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT240730 NZ_LT615378:4349058-4349354 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References