Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1161139..1161653 Replicon chromosome
Accession NZ_CP094923
Organism Staphylococcus aureus strain 1824

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MUO47_RS05840 Protein ID WP_000581792.1
Coordinates 1161139..1161348 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag MUO47_RS05845 Protein ID WP_000138932.1
Coordinates 1161360..1161653 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUO47_RS05820 (MUO47_05805) 1156647..1158005 - 1359 WP_000611471.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MUO47_RS05825 (MUO47_05810) 1158020..1159090 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
MUO47_RS05830 (MUO47_05815) 1159408..1160610 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MUO47_RS05835 (MUO47_05820) 1160874..1161011 - 138 WP_000828354.1 Lmo0850 family protein -
MUO47_RS05840 (MUO47_05825) 1161139..1161348 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MUO47_RS05845 (MUO47_05830) 1161360..1161653 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUO47_RS05850 (MUO47_05835) 1161819..1163303 + 1485 WP_000571549.1 cardiolipin synthase -
MUO47_RS05855 (MUO47_05840) 1163331..1163978 + 648 WP_001187630.1 HD domain-containing protein -
MUO47_RS05860 (MUO47_05845) 1164583..1165455 - 873 WP_277445901.1 membrane protein insertase YidC -
MUO47_RS05865 (MUO47_05850) 1165541..1166182 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T240728 WP_000581792.1 NZ_CP094923:c1161348-1161139 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T240728 NZ_LT615378:3273849-3274313 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT240728 WP_000138932.1 NZ_CP094923:c1161653-1161360 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT240728 NZ_LT615378:3273514-3273849 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References