Detailed information of TA system TA240725

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 2388102..2389786
• Replicon: chromosome
• Accession: NZ_CP094879
• Organism: Thalassolituus sp. C2-1

Toxin (Protein)

• Gene name: HipA3
• Uniprot ID: -
• Locus tag: MT343_RS10580
• Protein ID: WP_145468363.1
• Coordinates: 2388102..2389430 (-)
• Length: 443 a.a.

Antitoxin (Protein)

• Gene name: HipB3
• Uniprot ID: -
• Locus tag: MT343_RS10585
• Protein ID: WP_145468361.1
• Coordinates: 2389424..2389786 (-)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MT343_RS10560	2383285..2384757	+	1473	WP_145468371.1	RimK family protein	-
MT343_RS10565	2384894..2385679	+	786	WP_145468369.1	transporter substrate-binding domain-containing protein	-
MT343_RS10570	2385947..2387074	+	1128	WP_145468367.1	response regulator	-
MT343_RS10575	2387065..2388105	-	1041	WP_145468365.1	DUF3524 domain-containing protein	-
MT343_RS10580	2388102..2389430	-	1329	WP_145468363.1	type II toxin-antitoxin system HipA family toxin	Toxin
MT343_RS10585	2389424..2389786	-	363	WP_145468361.1	helix-turn-helix transcriptional regulator	Antitoxin
MT343_RS10590	2389956..2391299	-	1344	WP_145468359.1	30S ribosomal protein S12 methylthiotransferase RimO	-
MT343_RS10595	2391487..2392746	-	1260	WP_243989384.1	dicarboxylate/amino acid:cation symporter	-
MT343_RS10600	2393037..2393741	+	705	WP_145468357.1	pseudouridine synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (17-121)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-71)

Sequences

Toxin

Protein

• Length: 443 a.a.
• Molecular weight: 49208.05 Da
• Isoelectric Point: 7.2607

>T240725 WP_145468363.1 NZ_CP094879:c2389430-2388102 [Thalassolituus sp. C2-1]
MVMEAIRVQYAEGAVTHSVGAVSFDTTTGQGAFEYSPEFIRSGIELAPLTMPLAAGVYRFPQLGFATFKGLPGLIADSLP
DDFGNAVLNAWVASRGKRPQDITPLQRLQYTGKRGMGALEFAPATRLKSLNASQQVEIHALVEIAQDILDKRSDFQVTLD
QYGADDKEAMLALLSVGMSAGGARPKAVLAFNENFTQARSGQTDVPAGFSHYLMKFDGVSEHNQNTETFGDPMGYGAMEY
VYAQMAQACGIQMMPCYLLAEGDRRHFLTQRFDRAGNDKIHMQTLNGLAHVDYKKPGSFSYAELFAVARRLKLSAPEAEQ
ILRRMIFNIVARNHDDHAKNTAFLYLNRKWSLAPAYDLAYSYKPGSPWVNSHWMSLNGKRDAFTREDIYSLEKLSPLFSR
RKLNTVIDEVIEQVSRWPQLAKEQGVPLSLVNEITANLRLTL

Nucleotide

• Length: 1329 bp

>T240725 NZ_LT615378:c3037126-3036719 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 12784.49 Da
• Isoelectric Point: 6.3214

>AT240725 WP_145468361.1 NZ_CP094879:c2389786-2389424 [Thalassolituus sp. C2-1]
MSSVSSYSDLSPAALSELLGERLKLARLNQDLTQAQVAEQAGVSRKVVINAEKGKASLEVFVALLQALNQVSQLDQFLPP
QTLSPLQLAKLQGKRRQRASGLGLGQQAADTGPAEEDGSW

Nucleotide

• Length: 363 bp

>AT240725 NZ_LT615378:c3037373-3037107 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA