Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2000235..2000705 | Replicon | chromosome |
| Accession | NZ_CP094872 | ||
| Organism | Staphylococcus epidermidis strain C101 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | Q5HQS5 |
| Locus tag | MUG62_RS09460 | Protein ID | WP_001829569.1 |
| Coordinates | 2000517..2000705 (+) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | D4FNP2 |
| Locus tag | MUG62_RS09455 | Protein ID | WP_002438963.1 |
| Coordinates | 2000235..2000492 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUG62_RS09415 (MUG62_09415) | 1995599..1996315 | - | 717 | WP_001831974.1 | type I 3-dehydroquinate dehydratase | - |
| MUG62_RS09420 (MUG62_09420) | 1996476..1996898 | + | 423 | WP_002457221.1 | organic hydroperoxide resistance protein | - |
| MUG62_RS09425 (MUG62_09425) | 1997082..1997237 | - | 156 | WP_001829648.1 | hypothetical protein | - |
| MUG62_RS09430 (MUG62_09430) | 1997249..1997436 | - | 188 | Protein_1831 | hypothetical protein | - |
| MUG62_RS09435 (MUG62_09435) | 1997823..1998323 | + | 501 | WP_001829623.1 | GNAT family N-acetyltransferase | - |
| MUG62_RS09440 (MUG62_09440) | 1998594..1999181 | - | 588 | WP_001829615.1 | histidine phosphatase family protein | - |
| MUG62_RS09445 (MUG62_09445) | 1999395..1999631 | + | 237 | WP_002457224.1 | hypothetical protein | - |
| MUG62_RS09450 (MUG62_09450) | 1999623..1999826 | - | 204 | WP_001829671.1 | sterile alpha motif-like domain-containing protein | - |
| MUG62_RS09455 (MUG62_09455) | 2000235..2000492 | + | 258 | WP_002438963.1 | hypothetical protein | Antitoxin |
| MUG62_RS09460 (MUG62_09460) | 2000517..2000705 | + | 189 | WP_001829569.1 | hypothetical protein | Toxin |
| MUG62_RS09465 (MUG62_09465) | 2000895..2001449 | + | 555 | WP_001829566.1 | lipoprotein N-acylation protein LnsA | - |
| MUG62_RS09470 (MUG62_09470) | 2001509..2001742 | - | 234 | WP_001829664.1 | hypothetical protein | - |
| MUG62_RS09475 (MUG62_09475) | 2002027..2002773 | + | 747 | WP_001829580.1 | poly-gamma-glutamate hydrolase family protein | - |
| MUG62_RS09480 (MUG62_09480) | 2002872..2003156 | + | 285 | WP_001829635.1 | hypothetical protein | - |
| MUG62_RS09485 (MUG62_09485) | 2003180..2003404 | + | 225 | WP_001829613.1 | hypothetical protein | - |
| MUG62_RS09490 (MUG62_09490) | 2004025..2004225 | - | 201 | WP_001829681.1 | cold-shock protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | dfrG | - | 1997082..2022201 | 25119 | |
| - | flank | IS/Tn | - | - | 1997082..1997237 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7229.94 Da Isoelectric Point: 9.7844
>T240724 WP_001829569.1 NZ_CP094872:2000517-2000705 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL
Download Length: 189 bp
>T240724 NZ_LT615378:c2907395-2907060 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 10014.05 Da Isoelectric Point: 4.5440
>AT240724 WP_002438963.1 NZ_CP094872:2000235-2000492 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV
Download Length: 258 bp
>AT240724 NZ_LT615378:c2907643-2907395 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0N0LUH8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0U5IVM3 |