240723

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_XRE(antitoxin)
Location 1858942..1859744 Replicon chromosome
Accession NZ_CP094872
Organism Staphylococcus epidermidis strain C101

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag MUG62_RS08710 Protein ID WP_002469232.1
Coordinates 1859283..1859744 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag MUG62_RS08705 Protein ID WP_002439260.1
Coordinates 1858942..1859271 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUG62_RS08655 (MUG62_08655) 1853986..1854201 + 216 WP_001831694.1 NINE protein -
MUG62_RS08660 (MUG62_08660) 1854742..1855272 + 531 WP_237625884.1 N-acetyltransferase -
MUG62_RS08665 (MUG62_08665) 1855508..1855705 + 198 WP_002456096.1 hypothetical protein -
MUG62_RS08670 (MUG62_08670) 1856046..1856279 - 234 Protein_1678 AAA family ATPase -
MUG62_RS08675 (MUG62_08675) 1856654..1856977 + 324 WP_002456098.1 hypothetical protein -
MUG62_RS12090 1856960..1857094 - 135 WP_002439268.1 hypothetical protein -
MUG62_RS08680 (MUG62_08680) 1857108..1857320 - 213 Protein_1681 DUF771 domain-containing protein -
MUG62_RS08685 (MUG62_08685) 1857324..1858088 - 765 WP_237625885.1 phage regulatory protein/antirepressor Ant -
MUG62_RS08690 (MUG62_08690) 1858138..1858344 + 207 WP_002439266.1 hypothetical protein -
MUG62_RS08695 (MUG62_08695) 1858333..1858497 - 165 WP_002439265.1 hypothetical protein -
MUG62_RS08700 (MUG62_08700) 1858494..1858748 - 255 WP_237625886.1 helix-turn-helix transcriptional regulator -
MUG62_RS08705 (MUG62_08705) 1858942..1859271 + 330 WP_002439260.1 helix-turn-helix transcriptional regulator Antitoxin
MUG62_RS08710 (MUG62_08710) 1859283..1859744 + 462 WP_002469232.1 ImmA/IrrE family metallo-endopeptidase Toxin
MUG62_RS08715 (MUG62_08715) 1859760..1860278 + 519 WP_002439256.1 hypothetical protein -
MUG62_RS08720 (MUG62_08720) 1860280..1860723 + 444 WP_237625888.1 hypothetical protein -
MUG62_RS08725 (MUG62_08725) 1860796..1860990 + 195 WP_002439253.1 hypothetical protein -
MUG62_RS08730 (MUG62_08730) 1861059..1861574 + 516 WP_002439252.1 hypothetical protein -
MUG62_RS08735 (MUG62_08735) 1861576..1861911 + 336 WP_002439251.1 hypothetical protein -
MUG62_RS08740 (MUG62_08740) 1861967..1862365 + 399 Protein_1693 phage integrase SAM-like domain-containing protein -
MUG62_RS08745 (MUG62_08745) 1862471..1863031 + 561 WP_279594400.1 site-specific integrase -
MUG62_RS08760 (MUG62_08760) 1863537..1864112 - 576 WP_001829272.1 competence protein ComK -
MUG62_RS08765 (MUG62_08765) 1864327..1864545 + 219 WP_001829292.1 IDEAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1856034..1863031 6997


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(25-119)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-65)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18327.03 Da        Isoelectric Point: 6.8511

>T240723 WP_002469232.1 NZ_CP094872:1859283-1859744 [Staphylococcus epidermidis]
MGLYEKMLIKHDYIEVRETNVMPNDLHGLWLGDLILIKRNLSETRKAEVLYEELTHHKLTYGNILDQSKFNNRKFENYAR
RYGYEAALPLRIIVEAHNYGISNLYELAEYVQLSEEYIVEILKHYKNKYGIGTHYGEYLITFDPLRVFKYKEI

Download         Length: 462 bp

>T240723 NZ_LT615378:2773757-2774086 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12735.32 Da        Isoelectric Point: 5.7917

>AT240723 WP_002439260.1 NZ_CP094872:1858942-1859271 [Staphylococcus epidermidis]
MRNNDEIITIIKSAMKEQDMSLSELARRVGVAKSAVSRYLNLTREFPLNRTEDFAKALSISTEYLLGFDKSEQQDEQPKH
RAAHLEGELTDEEWQRVLDYADYIRSKRK

Download         Length: 330 bp

>AT240723 NZ_LT615378:2773419-2773736 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References