Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 874851..875380 Replicon chromosome
Accession NZ_CP094872
Organism Staphylococcus epidermidis strain C101

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag MUG62_RS04035 Protein ID WP_001829891.1
Coordinates 875018..875380 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag MUG62_RS04030 Protein ID WP_001829931.1
Coordinates 874851..875021 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUG62_RS04005 (MUG62_04005) 870676..871155 + 480 WP_001829909.1 PH domain-containing protein -
MUG62_RS04010 (MUG62_04010) 871148..872653 + 1506 WP_001829976.1 PH domain-containing protein -
MUG62_RS04015 (MUG62_04015) 872640..873149 + 510 WP_001829888.1 PH domain-containing protein -
MUG62_RS04020 (MUG62_04020) 873197..873550 + 354 WP_001829915.1 holo-ACP synthase -
MUG62_RS04025 (MUG62_04025) 873616..874764 + 1149 WP_002489359.1 alanine racemase -
MUG62_RS04030 (MUG62_04030) 874851..875021 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MUG62_RS04035 (MUG62_04035) 875018..875380 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MUG62_RS04040 (MUG62_04040) 875725..876726 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
MUG62_RS04045 (MUG62_04045) 876826..877152 + 327 WP_001829952.1 anti-sigma factor antagonist -
MUG62_RS04050 (MUG62_04050) 877154..877633 + 480 WP_001829903.1 anti-sigma B factor RsbW -
MUG62_RS04055 (MUG62_04055) 877608..878378 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T240721 WP_001829891.1 NZ_CP094872:875018-875380 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T240721 NZ_LT615378:c2092649-2092398 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT240721 WP_001829931.1 NZ_CP094872:874851-875021 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT240721 NZ_LT615378:c2092401-2092147 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References