240720

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 863668..864177 Replicon chromosome
Accession NZ_CP094872
Organism Staphylococcus epidermidis strain C101

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag MUG62_RS03975 Protein ID WP_001829980.1
Coordinates 863968..864177 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag MUG62_RS03970 Protein ID WP_001829893.1
Coordinates 863668..863961 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUG62_RS03945 (MUG62_03945) 858676..859464 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
MUG62_RS03950 (MUG62_03950) 859470..860108 + 639 WP_002505076.1 thiamine phosphate synthase -
MUG62_RS03955 (MUG62_03955) 860197..861069 + 873 WP_002458703.1 membrane protein insertase YidC -
MUG62_RS03960 (MUG62_03960) 861175..861828 - 654 WP_001829983.1 HD domain-containing protein -
MUG62_RS03965 (MUG62_03965) 862010..863494 - 1485 WP_002457116.1 cardiolipin synthase -
MUG62_RS03970 (MUG62_03970) 863668..863961 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
MUG62_RS03975 (MUG62_03975) 863968..864177 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
MUG62_RS03980 (MUG62_03980) 864320..864457 + 138 WP_001829949.1 Lmo0850 family protein -
MUG62_RS03985 (MUG62_03985) 864557..865768 - 1212 WP_001829910.1 FtsW/RodA/SpoVE family cell cycle protein -
MUG62_RS03990 (MUG62_03990) 866159..867232 + 1074 WP_001832735.1 D-alanine--D-alanine ligase -
MUG62_RS03995 (MUG62_03995) 867244..868599 + 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T240720 WP_001829980.1 NZ_CP094872:863968-864177 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T240720 NZ_LT615378:c2092401-2092147 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT240720 WP_001829893.1 NZ_CP094872:863668-863961 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT240720 NZ_LT615378:c2092649-2092398 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References