Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2e+06..2000470 Replicon chromosome
Accession NZ_CP094865
Organism Staphylococcus epidermidis strain C100

Toxin (Protein)


Gene name TsaT Uniprot ID Q5HQS5
Locus tag MUG64_RS09460 Protein ID WP_001829569.1
Coordinates 2000282..2000470 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID D4FNP2
Locus tag MUG64_RS09455 Protein ID WP_002438963.1
Coordinates 2000000..2000257 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUG64_RS09415 (MUG64_09415) 1995364..1996080 - 717 WP_001831974.1 type I 3-dehydroquinate dehydratase -
MUG64_RS09420 (MUG64_09420) 1996241..1996663 + 423 WP_002457221.1 organic hydroperoxide resistance protein -
MUG64_RS09425 (MUG64_09425) 1996847..1997002 - 156 WP_001829648.1 hypothetical protein -
MUG64_RS09430 (MUG64_09430) 1997014..1997201 - 188 Protein_1831 hypothetical protein -
MUG64_RS09435 (MUG64_09435) 1997588..1998088 + 501 WP_001829623.1 GNAT family N-acetyltransferase -
MUG64_RS09440 (MUG64_09440) 1998359..1998946 - 588 WP_001829615.1 histidine phosphatase family protein -
MUG64_RS09445 (MUG64_09445) 1999160..1999396 + 237 WP_002457224.1 hypothetical protein -
MUG64_RS09450 (MUG64_09450) 1999388..1999591 - 204 WP_001829671.1 sterile alpha motif-like domain-containing protein -
MUG64_RS09455 (MUG64_09455) 2000000..2000257 + 258 WP_002438963.1 hypothetical protein Antitoxin
MUG64_RS09460 (MUG64_09460) 2000282..2000470 + 189 WP_001829569.1 hypothetical protein Toxin
MUG64_RS09465 (MUG64_09465) 2000660..2001214 + 555 WP_001829566.1 lipoprotein N-acylation protein LnsA -
MUG64_RS09470 (MUG64_09470) 2001274..2001507 - 234 WP_001829664.1 hypothetical protein -
MUG64_RS09475 (MUG64_09475) 2001792..2002538 + 747 WP_001829580.1 poly-gamma-glutamate hydrolase family protein -
MUG64_RS09480 (MUG64_09480) 2002637..2002921 + 285 WP_001829635.1 hypothetical protein -
MUG64_RS09485 (MUG64_09485) 2002945..2003169 + 225 WP_001829613.1 hypothetical protein -
MUG64_RS09490 (MUG64_09490) 2003790..2003990 - 201 WP_001829681.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage dfrG - 1996847..2021965 25118
- flank IS/Tn - - 1996847..1997002 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7229.94 Da        Isoelectric Point: 9.7844

>T240719 WP_001829569.1 NZ_CP094865:2000282-2000470 [Staphylococcus epidermidis]
MSLHFQILLWLSILFIIAGTILLVTMLKTKKEERKESYLGFTVIFLIFGFAILIYTFIFGIL

Download         Length: 189 bp

>T240719 NZ_LT615378:2080505-2080879 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10014.05 Da        Isoelectric Point: 4.5440

>AT240719 WP_002438963.1 NZ_CP094865:2e+06-2000257 [Staphylococcus epidermidis]
MKLNKANIFNLIFTILFFSFNILITYNANIDYKLWLIPGLAICGFALFSSLTLVIIYSDLFSEILFFINIILALYYIYPI
FYEFV

Download         Length: 258 bp

>AT240719 NZ_LT615378:2080048-2080416 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGATTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0N0LUH8

Antitoxin

Source ID Structure
AlphaFold DB A0A0U5IVM3

References